A Trichinella spiralis serine protease triggers gut epithelial apoptosis and destroys the barrier integrity to mediate larval invasion

Qi Qi Lu; Xin Zhuo Zhang; Pei Kun Cong; Jin Yi Wu; Tian Ran Gao; Shao Rong Long; Ruo Dan Liu; Zhong Quan Wang; Jing Cui

doi:10.1371/journal.pntd.0013680

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Open Access

Peer-reviewed

Research Article

A Trichinella spiralis serine protease triggers gut epithelial apoptosis and destroys the barrier integrity to mediate larval invasion

Qi Qi Lu,

Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
⨯
Xin Zhuo Zhang,

Roles Investigation

Affiliation Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
⨯
Pei Kun Cong,

Roles Investigation

Affiliation Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
⨯
Jin Yi Wu,

Roles Investigation

Affiliation Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
⨯
Tian Ran Gao,

Roles Investigation

Affiliation Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
⨯
Shao Rong Long,

Roles Investigation

Affiliation Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
⨯
Ruo Dan Liu ,

Roles Investigation, Supervision

* E-mail: liuruodan2006@126.com (RDL); wangzq@zzu.edu.cn (ZQW); cuij@zzu.edu.cn (JC)

Affiliation Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
⨯
Zhong Quan Wang ,

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: liuruodan2006@126.com (RDL); wangzq@zzu.edu.cn (ZQW); cuij@zzu.edu.cn (JC)

Affiliation Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
⨯
Jing Cui

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: liuruodan2006@126.com (RDL); wangzq@zzu.edu.cn (ZQW); cuij@zzu.edu.cn (JC)

Affiliation Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China

https://orcid.org/0000-0001-8726-5498

⨯

A Trichinella spiralis serine protease triggers gut epithelial apoptosis and destroys the barrier integrity to mediate larval invasion

Qi Qi Lu,
Xin Zhuo Zhang,
Pei Kun Cong,
Jin Yi Wu,
Tian Ran Gao,
Shao Rong Long,
Ruo Dan Liu,
Zhong Quan Wang,
Jing Cui

Published: October 30, 2025
https://doi.org/10.1371/journal.pntd.0013680

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Apoptosis
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Caco-2 cells
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Larvae
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Gastrointestinal tract
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Protein expression
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DAPI staining
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