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Open Access
Peer-reviewed
Research Article
Schistosoma haematobium infection is associated with oncogenic gene expression in Cervical Mucosa, with enhanced effects following treatment: A pilot study
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Anna M. Mertelsmann ,
Contributed equally to this work with: Anna M. Mertelsmann, Jane K. Maganga, Jennifer A. Downs, John M. Changalucha
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: annamertelsmann@gmail.com
Affiliations Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland, University of Zurich, Zurich, Switzerland, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, United States of America, Center for Global Health, Weill Cornell Medicine, New York, New York, United States of America
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Jane K. Maganga ,
Contributed equally to this work with: Anna M. Mertelsmann, Jane K. Maganga, Jennifer A. Downs, John M. Changalucha
Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing
Affiliation Mwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania
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Myung Hee Lee,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing
Affiliation Center for Global Health, Weill Cornell Medicine, New York, New York, United States of America
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Maureen Ward,
Roles Data curation, Methodology, Project administration, Writing – original draft, Writing – review & editing
Affiliation Center for Global Health, Weill Cornell Medicine, New York, New York, United States of America
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Adrian Y. Tan,
Roles Data curation, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing
Affiliation Genomics Resources Core Facility, Weill Cornell Medicine, New York, New York, United States of America
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Sheridan F. Bowers,
Roles Conceptualization, Data curation, Methodology, Writing – review & editing
Affiliation Center for Global Health, Weill Cornell Medicine, New York, New York, United States of America
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Loyce Mhango,
Roles Data curation, Investigation, Methodology, Writing – review & editing
Affiliation Mwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania
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Danielle de Jong,
Roles Methodology, Validation, Writing – review & editing
Affiliation Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands
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Paul L.A.M. Corstjens,
Roles Methodology, Validation, Writing – review & editing
Affiliation Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands
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Govert J. van Dam,
Roles Methodology, Validation, Writing – review & editing
Affiliation Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands
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Saidi H. Kapiga,
Roles Investigation, Supervision, Writing – review & editing
Affiliations Mwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Kathryn M. Dupnik,
Roles Investigation, Methodology, Supervision, Validation, Writing – review & editing
Affiliations Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, United States of America, Center for Global Health, Weill Cornell Medicine, New York, New York, United States of America
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Humphrey D. Mazigo,
Roles Investigation, Writing – review & editing
Affiliation Department of Parasitology and Entomology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania
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Jennifer A. Downs ,
Contributed equally to this work with: Anna M. Mertelsmann, Jane K. Maganga, Jennifer A. Downs, John M. Changalucha
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing
Affiliations Center for Global Health, Weill Cornell Medicine, New York, New York, United States of America, Mwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania, Department of Medicine, Weill Bugando School of Medicine, Mwanza, Tanzania
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John M. Changalucha
Contributed equally to this work with: Anna M. Mertelsmann, Jane K. Maganga, Jennifer A. Downs, John M. Changalucha
Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing
Affiliation Mwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania
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Schistosoma haematobium infection is associated with oncogenic gene expression in Cervical Mucosa, with enhanced effects following treatment: A pilot study
- Anna M. Mertelsmann,
- Jane K. Maganga,
- Myung Hee Lee,
- Maureen Ward,
- Adrian Y. Tan,
- Sheridan F. Bowers,
- Loyce Mhango,
- Danielle de Jong,
- Paul L.A.M. Corstjens,
- Govert J. van Dam
- Published: November 21, 2025
- https://doi.org/10.1371/journal.pntd.0013569