Differentiating proven progressive disseminated histoplasmosis from other diagnoses in hospitalized persons with HIV and suspected progressive disseminated histoplasmosis: Findings from a clinical and demographic study in Mexico

Maria Dolores Niembro-Ortega; Areli Martinez-Gamboa; Antonio Olivas-Martinez; Brenda Crabtree-Ramirez; Janeth Santiago-Cruz; Andrea Rangel-Cordero; Pedro Torres-Gonzalez; Armando Gamboa-Dominguez; Victor Hugo Lozano-Fernandez; Victor Hugo Ahumada-Topete; Pedro Martinez-Ayala; Marisol Manriquez-Reyes; Juan Pablo Ramirez-Hinojosa; Patricia Rodriguez-Zulueta; Jesus Ruiz-Quiñones; Christian Hernandez-Leon; Norma Erendira Rivera-Martinez; Alberto Chaparro-Sanchez; Jaime Andrade-Villanueva; Luz Alicia Gonzalez-Hernandez; Sofia Cruz-Martinez; Oscar Flores-Barrientos; Jesus Enrique Gaytan-Martinez; Axel Cervantes Sanchez; Nancy Guadalupe Velazquez-Zavala; Maria del Rocio Reyes-Montes; Esperanza Duarte Escalante; Maria Guadalupe Frias De Leon; Jose Antonio Ramirez; Maria Lucia Taylor; Jose Sifuentes-Osornio; Alfredo Ponce de Leon

doi:10.1371/journal.pntd.0013527

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Open Access

Peer-reviewed

Research Article

Differentiating proven progressive disseminated histoplasmosis from other diagnoses in hospitalized persons with HIV and suspected progressive disseminated histoplasmosis: Findings from a clinical and demographic study in Mexico

Maria Dolores Niembro-Ortega,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
⨯
Areli Martinez-Gamboa,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
⨯
Antonio Olivas-Martinez,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Writing – original draft, Writing – review & editing

Affiliations Departmet of Medicine, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
⨯
Brenda Crabtree-Ramirez,

Roles Conceptualization, Formal analysis, Writing – original draft

Affiliation Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
⨯
Janeth Santiago-Cruz,

Roles Data curation, Investigation, Methodology, Resources, Writing – original draft

Affiliation Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
⨯
Andrea Rangel-Cordero,

Roles Data curation, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
⨯
Pedro Torres-Gonzalez,

Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Writing – original draft

Affiliation Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
⨯
Armando Gamboa-Dominguez,

Roles Data curation, Investigation, Resources, Writing – original draft

Affiliation Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
⨯
Victor Hugo Lozano-Fernandez,

Roles Data curation, Investigation, Resources, Writing – original draft

Affiliation Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas”, Mexico City, Mexico
⨯
Victor Hugo Ahumada-Topete,

Roles Data curation, Investigation, Resources, Writing – original draft

Affiliation Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas”, Mexico City, Mexico
⨯
Pedro Martinez-Ayala,

Roles Conceptualization, Data curation, Investigation, Resources, Writing – original draft

Affiliation HIV Unit, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara, Jalisco, Mexico
⨯
Marisol Manriquez-Reyes,

Roles Data curation, Investigation, Resources, Writing – original draft

Affiliation Department of Internal Medicine, Hospital de Alta Especialidad de Veracruz, Veracruz, Veracruz, Mexico
⨯
Juan Pablo Ramirez-Hinojosa,

Roles Data curation, Investigation, Resources

Affiliation Department of Infectious Diseases, Hospital General “Dr. Manuel Gea González”, Mexico City, Mexico
⨯
Patricia Rodriguez-Zulueta,

Roles Data curation, Investigation, Resources

Affiliation Department of Infectious Diseases, Hospital General “Dr. Manuel Gea González”, Mexico City, Mexico
⨯
Jesus Ruiz-Quiñones,

Roles Data curation, Investigation, Resources, Writing – original draft

Affiliation Intensive Care Unit, Department of Internal Medicine, Hospital “Dr. Juan Graham Casasus”, Villahermosa, Tabasco, Mexico
⨯
Christian Hernandez-Leon,

Roles Data curation, Investigation, Resources

Affiliation Area of Infectious Diseases, Department of Internal Medicine, Hospital General de Puebla “Dr. Eduardo Vázquez Navarro”, Puebla, Puebla, Mexico
⨯
Norma Erendira Rivera-Martinez,

Roles Data curation, Investigation, Resources, Writing – original draft

Affiliation Adult Infectious Diseases Department, Hospital Regional de Alta Especialidad de Oaxaca, HRAEO, San Bartolo Coyotepec, Oaxaca, Mexico
⨯
Alberto Chaparro-Sanchez,

Roles Data curation, Investigation, Resources

Affiliation Department of Infectious Diseases, Hospital de Infectología del Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social, Azcapotzalco, Mexico City, Mexico
⨯
Jaime Andrade-Villanueva,

Roles Data curation, Investigation, Resources

Affiliation HIV Unit, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara, Jalisco, Mexico
⨯
Luz Alicia Gonzalez-Hernandez,

Roles Data curation, Investigation, Resources

Affiliation HIV Unit, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara, Jalisco, Mexico
⨯
Sofia Cruz-Martinez,

Roles Data curation, Investigation, Resources

Affiliation Adult Infectious Diseases Department, Hospital Regional de Alta Especialidad de Oaxaca, HRAEO, San Bartolo Coyotepec, Oaxaca, Mexico
⨯
Oscar Flores-Barrientos,

Roles Data curation, Investigation, Resources

Affiliation Intensive Care Unit, Department of Internal Medicine, Hospital “Dr. Juan Graham Casasus”, Villahermosa, Tabasco, Mexico
⨯
Jesus Enrique Gaytan-Martinez,

Roles Data curation, Investigation, Resources

Affiliation Department of Infectious Diseases, Hospital de Infectología del Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social, Azcapotzalco, Mexico City, Mexico
⨯
Axel Cervantes Sanchez,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
⨯
Nancy Guadalupe Velazquez-Zavala,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
⨯
Maria del Rocio Reyes-Montes,

Roles Data curation, Investigation, Resources

Affiliation Mycology Unit, Department of Microbiology and Parasitology, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Esperanza Duarte Escalante,

Roles Data curation, Investigation, Resources

Affiliation Mycology Unit, Department of Microbiology and Parasitology, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Maria Guadalupe Frias De Leon,

Roles Data curation, Investigation, Resources

Affiliation Mycology Unit, Department of Microbiology and Parasitology, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Jose Antonio Ramirez,

Roles Data curation, Investigation, Resources

Affiliation Mycology Unit, Department of Microbiology and Parasitology, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Maria Lucia Taylor,

Roles Data curation, Investigation, Resources, Writing – original draft

Affiliation Mycology Unit, Department of Microbiology and Parasitology, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Jose Sifuentes-Osornio ,

Roles Conceptualization, Formal analysis, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: alf.poncedeleon@gmail.com (APL); jose.sifuenteso@incmnsz.mx (JSO)

Affiliation General director at Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubiran”, Mexico City, Mexico
⨯
[ ... ],
Alfredo Ponce de Leon

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: alf.poncedeleon@gmail.com (APL); jose.sifuenteso@incmnsz.mx (JSO)

Affiliation Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico

https://orcid.org/0000-0003-2640-2916

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Differentiating proven progressive disseminated histoplasmosis from other diagnoses in hospitalized persons with HIV and suspected progressive disseminated histoplasmosis: Findings from a clinical and demographic study in Mexico

Maria Dolores Niembro-Ortega,
Areli Martinez-Gamboa,
Antonio Olivas-Martinez,
Brenda Crabtree-Ramirez,
Janeth Santiago-Cruz,
Andrea Rangel-Cordero,
Pedro Torres-Gonzalez,
Armando Gamboa-Dominguez,
Victor Hugo Lozano-Fernandez,
Victor Hugo Ahumada-Topete

Published: September 17, 2025
https://doi.org/10.1371/journal.pntd.0013527

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