Ginkgolic acid attenuates echinococcus granulosus infection-induced hepatic fibrosis by inhibiting Smad4 SUMOylation

Qiuyue Chen; Dan Dong; Xueting Yu; Xinyu Jiang; Huijiao Jiang; Jun Hou; Lianghai Wang; Junying Xu; Xiangwei Wu; Xueling Chen

doi:10.1371/journal.pntd.0013497

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Open Access

Peer-reviewed

Research Article

Ginkgolic acid attenuates echinococcus granulosus infection-induced hepatic fibrosis by inhibiting Smad4 SUMOylation

Qiuyue Chen ,

Contributed equally to this work with: Qiuyue Chen, Dan Dong

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Shihezi University School of Medicine, Shihezi, China, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, China, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, China
⨯
Dan Dong ,

Contributed equally to this work with: Qiuyue Chen, Dan Dong

Roles Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Shihezi University School of Medicine, Shihezi, China, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, China, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, China
⨯
Xueting Yu,

Roles Data curation, Investigation

Affiliations Shihezi University School of Medicine, Shihezi, China, Huludao Center for Disease Control and Prevention (Municipal Institute of Health Supervision), Liaoning Province, China
⨯
Xinyu Jiang,

Roles Formal analysis, Investigation

Affiliations Shihezi University School of Medicine, Shihezi, China, The First Affiliated Hospital of Shihezi University, Shihezi, China, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, China, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, China
⨯
Huijiao Jiang,

Roles Funding acquisition, Investigation

Affiliations Shihezi University School of Medicine, Shihezi, China, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, China, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, China
⨯
Jun Hou,

Roles Investigation, Methodology, Supervision

Affiliations Shihezi University School of Medicine, Shihezi, China, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, China, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, China
⨯
Lianghai Wang,

Roles Investigation, Methodology, Software, Supervision

Affiliations Shihezi University School of Medicine, Shihezi, China, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, China, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, China
⨯
Junying Xu,

Roles Investigation, Software

Affiliations Shihezi University School of Medicine, Shihezi, China, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, China, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, China
⨯
Xiangwei Wu ,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: wxwshz@126.com (XW); chenxueling@shzu.edu.cn (XC)

Affiliations Shihezi University School of Medicine, Shihezi, China, The First Affiliated Hospital of Shihezi University, Shihezi, China, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, China, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, China
⨯
Xueling Chen

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: wxwshz@126.com (XW); chenxueling@shzu.edu.cn (XC)

Affiliations Shihezi University School of Medicine, Shihezi, China, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, China, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, China

https://orcid.org/0000-0002-4034-070X

⨯

Ginkgolic acid attenuates echinococcus granulosus infection-induced hepatic fibrosis by inhibiting Smad4 SUMOylation

Qiuyue Chen,
Dan Dong,
Xueting Yu,
Xinyu Jiang,
Huijiao Jiang,
Jun Hou,
Lianghai Wang,
Junying Xu,
Xiangwei Wu,
Xueling Chen

Published: January 13, 2026
https://doi.org/10.1371/journal.pntd.0013497

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