Molecular characterization of zinc metalloproteinase Nas-14 from Trichinella spiralis and its participation in intestinal invasion

Qingbo Lv; Guangquan Si; Chengyao Li; Ning Jiang; Yushu He; Zijian Dong; Hanhai Mao; Mingyuan Liu; Xiaolei Liu; Ying Zhao; Jing Ding

doi:10.1371/journal.pntd.0013437

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Open Access

Peer-reviewed

Research Article

Molecular characterization of zinc metalloproteinase Nas-14 from Trichinella spiralis and its participation in intestinal invasion

Qingbo Lv ,

Contributed equally to this work with: Qingbo Lv, Guangquan Si

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China

https://orcid.org/0000-0003-1158-7620

⨯
Guangquan Si ,

Contributed equally to this work with: Qingbo Lv, Guangquan Si

Roles Data curation, Investigation

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Chengyao Li,

Roles Formal analysis, Investigation

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China, China Conservation and Research Center for the Giant Panda, Key Laboratory of SFGA on the Giant Panda, Chengdu, Sichuan, China
⨯
Ning Jiang,

Roles Investigation

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Yushu He,

Roles Investigation

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Zijian Dong,

Roles Investigation

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Hanhai Mao,

Roles Investigation

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Mingyuan Liu,

Roles Supervision, Writing – review & editing

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China
⨯
Xiaolei Liu,

Roles Supervision, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Ying Zhao ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: zhaoying6688@jlu.edu.cn (YZ); dingjing900906@163.com (JD)

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China, Department of Nephrology, The First Hospital of Jilin University, Changchun, China
⨯
Jing Ding

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: zhaoying6688@jlu.edu.cn (YZ); dingjing900906@163.com (JD)

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China

https://orcid.org/0000-0001-9892-1657

⨯

Molecular characterization of zinc metalloproteinase Nas-14 from Trichinella spiralis and its participation in intestinal invasion

Qingbo Lv,
Guangquan Si,
Chengyao Li,
Ning Jiang,
Yushu He,
Zijian Dong,
Hanhai Mao,
Mingyuan Liu,
Xiaolei Liu,
Ying Zhao

Published: August 21, 2025
https://doi.org/10.1371/journal.pntd.0013437

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