Functional characterization of a common XIa inhibitory Kunitz-domain Shp4 from nine schistosoma secreted proteins with diverse C-terminal fragments

Xiangdong Ye; Xiaolin Deng; Huanhuan Gao; Shuwen Chen; Li Ding; Fang Sun; Chenhu Qin; Hongyi Luo; Wen Zhu; Xudong Luo; Zongyun Chen

doi:10.1371/journal.pntd.0013282

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Peer-reviewed

Research Article

Functional characterization of a common XIa inhibitory Kunitz-domain Shp4 from nine schistosoma secreted proteins with diverse C-terminal fragments

Xiangdong Ye ,

Contributed equally to this work with: Xiangdong Ye, Xiaolin Deng, Huanhuan Gao, Shuwen Chen

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization

Affiliations Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China, Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯
Xiaolin Deng ,

Contributed equally to this work with: Xiangdong Ye, Xiaolin Deng, Huanhuan Gao, Shuwen Chen

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

Affiliation Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯
Huanhuan Gao ,

Contributed equally to this work with: Xiangdong Ye, Xiaolin Deng, Huanhuan Gao, Shuwen Chen

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

Affiliation Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯
Shuwen Chen ,

Contributed equally to this work with: Xiangdong Ye, Xiaolin Deng, Huanhuan Gao, Shuwen Chen

Roles Data curation, Formal analysis, Funding acquisition, Software

Affiliation Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯
Li Ding,

Roles Data curation, Formal analysis, Software

Affiliations Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China, Department of Clinical Laboratory, Dongfeng Hospital, Hubei University of Medicine, Shiyan, China
⨯
Fang Sun,

Roles Data curation, Methodology

Affiliation Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯
Chenhu Qin,

Roles Data curation, Methodology

Affiliation Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯
Hongyi Luo,

Roles Formal analysis, Software

Affiliation Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯
Wen Zhu,

Roles Data curation, Methodology

Affiliation Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯
Xudong Luo ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: chenzy2005@126.com (ZC); luoxudong000@126.com (XL)

Affiliations Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China, Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯
Zongyun Chen

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: chenzy2005@126.com (ZC); luoxudong000@126.com (XL)

Affiliations Institute of Biomedicine, Hubei Key Laboratory of Embryonic Stem Cell Research and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China, Hubei Key Laboratory of Wudang Local Chinese Medicine Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, China
⨯

Functional characterization of a common XIa inhibitory Kunitz-domain Shp4 from nine schistosoma secreted proteins with diverse C-terminal fragments

Xiangdong Ye,
Xiaolin Deng,
Huanhuan Gao,
Shuwen Chen,
Li Ding,
Fang Sun,
Chenhu Qin,
Hongyi Luo,
Wen Zhu,
Xudong Luo

Published: July 8, 2025
https://doi.org/10.1371/journal.pntd.0013282

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