Long-term persistence and boostability of immune responses following different rabies pre-exposure prophylaxis priming schedules of a purified chick embryo cell rabies vaccine administered alone or concomitantly with a Japanese encephalitis vaccine

Tomas Jelinek; Mirjam Schunk; Emil C. Reisinger; Marylyn M. Addo; Ursula Wiedermann; Marco Costantini; Maria Lattanzi; Michele Pellegrini; Ilaria Galgani; on behalf of the Rabies-018 V49_23E1 study group

doi:10.1371/journal.pntd.0013118

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Open Access

Peer-reviewed

Research Article

Long-term persistence and boostability of immune responses following different rabies pre-exposure prophylaxis priming schedules of a purified chick embryo cell rabies vaccine administered alone or concomitantly with a Japanese encephalitis vaccine

Tomas Jelinek ,

Roles Conceptualization, Investigation, Validation, Writing – review & editing

¶‡ TJ and MS are co-first authors.

Affiliation Berlin Center for Travel and Tropical Medicine, Berlin, Germany
⨯
Mirjam Schunk ,

Roles Investigation, Validation, Writing – review & editing

¶‡ TJ and MS are co-first authors.

Affiliation Institute of Infectious Diseases and Tropical Medicine, LMU Klinikum, Munich, Germany
⨯
Emil C. Reisinger,

Roles Conceptualization, Investigation, Validation, Writing – review & editing

Affiliation Department of Tropical Medicine and Infectious Diseases, Rostock University Medical Center, Rostock, Germany
⨯
Marylyn M. Addo,

Roles Investigation, Validation, Writing – review & editing

Affiliation Bernhard Nocht Centre for Clinical Trials (BNCCT), Bernhard Nocht Institute for Tropical Medicine, Centre for Internal Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
⨯
Ursula Wiedermann,

Roles Investigation, Validation, Writing – review & editing

Affiliation Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
⨯
Marco Costantini,

Roles Conceptualization, Formal analysis, Validation, Writing – review & editing

Affiliation GSK, Siena, Italy
⨯
Maria Lattanzi,

Roles Conceptualization, Validation, Writing – review & editing

Affiliation GSK, Siena, Italy
⨯
Michele Pellegrini,

Roles Conceptualization, Writing – review & editing

Affiliation GSK, Siena, Italy
⨯
Ilaria Galgani ,

Roles Formal analysis, Validation, Writing – review & editing

* E-mail: ilaria.x.galgani@gsk.com

Affiliation GSK, Siena, Italy

https://orcid.org/0000-0001-6315-4259

⨯
on behalf of the Rabies-018 V49_23E1 study group

¶Membership of the Rabies-018 V49_23E1 study group is provided in the Acknowledgments.
⨯

Long-term persistence and boostability of immune responses following different rabies pre-exposure prophylaxis priming schedules of a purified chick embryo cell rabies vaccine administered alone or concomitantly with a Japanese encephalitis vaccine

Tomas Jelinek,
Mirjam Schunk,
Emil C. Reisinger,
Marylyn M. Addo,
Ursula Wiedermann,
Marco Costantini,
Maria Lattanzi,
Michele Pellegrini,
Ilaria Galgani,
on behalf of the Rabies-018 V49_23E1 study group

Published: May 27, 2025
https://doi.org/10.1371/journal.pntd.0013118

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