Clonorchis sinensis extracellular vesicles associated with Csi-let-7a-5p activate pro-inflammatory macrophages to induce biliary injury

• Beibei Zhang ,

  Contributed equally to this work with: Beibei Zhang, Xing Li

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Xing Li ,

  Contributed equally to this work with: Beibei Zhang, Xing Li

  Roles Data curation, Methodology, Writing – original draft

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Qian-Yang Zhou,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China, Department of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China

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• Chen Zhang,

  Roles Investigation

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Zheng-Rui Bian,

  Roles Methodology

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Xin-Xin Ren,

  Roles Investigation, Methodology

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Qian Yu,

  Roles Methodology

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Hui Hua,

  Roles Funding acquisition, Methodology

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Zhihua Jiang,

  Roles Funding acquisition, Resources

  Affiliation Institute of Parasitic Disease Control and Prevention, Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, China

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• Bo Zhang,

  Roles Methodology

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Xiang-Yang Li,

  Roles Methodology

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Mu-Xin Chen,

  Roles Funding acquisition, Investigation, Methodology, Resources

  Affiliations National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, Shanghai, People’s Republic of China, Hainan Tropical Diseases Research Center (Hainan Sub-Center, Chinese Center for Tropical Diseases Research), Haikou, People’s Republic of China

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• Kui-Yang Zheng ,

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: zky@xzhmu.edu.cn (K-YZ); yanchao6957@xzhmu.edu.cn (CY)

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

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• Chao Yan

  Roles Conceptualization, Supervision, Validation, Writing – review & editing

  * E-mail: zky@xzhmu.edu.cn (K-YZ); yanchao6957@xzhmu.edu.cn (CY)

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, National Demonstration Center for Experimental Basic Medical Science Education, Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Xuzhou Medical University, Xuzhou, People’s Republic of China

  https://orcid.org/0000-0002-7482-9116

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