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Open Access
Peer-reviewed
Research Article
Genomic hotspots in the DENV-2 serotype (E, NS4B, and NS5 genes) are associated with dengue disease severity in the endemic region of India
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Varsha Ravi ,
Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft
¶‡ These authors share first authorship on this work.
Affiliations Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India, Indraprastha Institute of Information Technology, Delhi, India
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Kriti Khare ,
Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft
¶‡ These authors share first authorship on this work.
Affiliations Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Ramakant Mohite,
Roles Investigation, Visualization, Writing – original draft
Affiliation Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India
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Pallavi Mishra,
Roles Formal analysis, Software
Affiliation Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India
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Sayanti Halder,
Roles Investigation
Affiliation Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India
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Richa Shukla,
Roles Investigation
Affiliation Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India
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Chinky Shiu Chen Liu,
Roles Investigation
Affiliation Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India
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Aanchal Yadav,
Roles Investigation
Affiliations Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Jyoti Soni,
Roles Investigation
Affiliations Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Kanika,
Affiliation Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India
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Komal Chaudhary,
Roles Resources
Affiliations Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India, Max Super Speciality Hospital (A Unit of Devki Devi Foundation), Max Healthcare, Delhi, India,
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Neha,
Affiliations Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India, Max Super Speciality Hospital (A Unit of Devki Devi Foundation), Max Healthcare, Delhi, India,
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Bansidhar Tarai,
Roles Resources
Affiliation Max Super Speciality Hospital (A Unit of Devki Devi Foundation), Max Healthcare, Delhi, India,
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Sandeep Budhiraja,
Roles Resources
Affiliation Max Super Speciality Hospital (A Unit of Devki Devi Foundation), Max Healthcare, Delhi, India,
⨯ - Pooja Khosla,
- Tavpritesh Sethi,
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Md Imran ,
Roles Conceptualization, Investigation, Methodology, Validation, Visualization, Writing – original draft
* E-mail: mdimran916@gmail.com (MI); rajesh.p@igib.res.in, rajeshp@igib.in (RP)
Affiliation Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India
⨯ - [ ... ],
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Rajesh Pandey
Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing
* E-mail: mdimran916@gmail.com (MI); rajesh.p@igib.res.in, rajeshp@igib.in (RP)
Affiliations Division of Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Genomic hotspots in the DENV-2 serotype (E, NS4B, and NS5 genes) are associated with dengue disease severity in the endemic region of India
- Varsha Ravi,
- Kriti Khare,
- Ramakant Mohite,
- Pallavi Mishra,
- Sayanti Halder,
- Richa Shukla,
- Chinky Shiu Chen Liu,
- Aanchal Yadav,
- Jyoti Soni,
- Kanika
- Published: April 29, 2025
- https://doi.org/10.1371/journal.pntd.0013034