Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease

• Frauke Assmus,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  ⨯
• Ayorinde Adehin,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  ⨯
• Richard M. Hoglund,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliations Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  ⨯
• Amanda Fortes Francisco,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

  ⨯
• Michael D. Lewis,

  Roles Writing – review & editing

  Affiliations Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom, Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom

  ⨯
• John M. Kelly,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

  ⨯
• Susan A. Charman,

  Roles Project administration, Supervision, Writing – review & editing

  Affiliation Centre for Drug Candidate Optimisation, Monash University, Melbourne, Australia

  ⨯
• Karen L. White,

  Roles Project administration, Writing – review & editing

  Affiliation Centre for Drug Candidate Optimisation, Monash University, Melbourne, Australia

  ⨯
• David M. Shackleford,

  Roles Investigation, Writing – review & editing

  Affiliation Centre for Drug Candidate Optimisation, Monash University, Melbourne, Australia

  ⨯
• Fanny Escudié,

  Roles Project administration, Supervision, Writing – review & editing

  Affiliation Drugs for Neglected Disease initiative, Geneva, Switzerland

  ⨯
• Eric Chatelain,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Drugs for Neglected Disease initiative, Geneva, Switzerland

  ⨯
• Ivan Scandale,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Drugs for Neglected Disease initiative, Geneva, Switzerland

  ⨯
• Joel Tarning

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: joel@tropmedres.ac

  Affiliations Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0003-4566-4030

  ⨯