Revisiting the Loa loa microfilaremia thresholds above which serious adverse events may occur with ivermectin treatment

Charlotte Boullé; Sébastien D. Pion; Jacques Gardon; Nathalie Gardon-Wendel; Joël Fokom Domgue; Joseph Kamgno; Cédric B. Chesnais; Michel Boussinesq

doi:10.1371/journal.pntd.0012957

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Open Access

Peer-reviewed

Research Article

Revisiting the Loa loa microfilaremia thresholds above which serious adverse events may occur with ivermectin treatment

Charlotte Boullé ,

Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: c-boulle@chu-montpellier.fr (CB); michel.boussinesq@ird.fr (MB)

Affiliations UMI 233, Institut de Recherche pour le Développement, INSERM Unité, Université de Montpellier, Montpellier, France, Department of Infectious and Tropical Diseases, Montpellier University Hospital, Montpellier, France

https://orcid.org/0000-0002-3800-6315

⨯
Sébastien D. Pion,

Roles Data curation, Methodology, Writing – review & editing

Affiliation UMI 233, Institut de Recherche pour le Développement, INSERM Unité, Université de Montpellier, Montpellier, France
⨯
Jacques Gardon,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Hydrosciences Montpellier, Université de Montpellier, Institut de Recherche pour le Développement, Centre National de la Recherche Scientifique, Montpellier, France
⨯
Nathalie Gardon-Wendel,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Centre Pasteur, Yaoundé, Cameroon
⨯
Joël Fokom Domgue,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Joseph Kamgno,

Roles Data curation, Investigation, Writing – review & editing

Affiliations Higher Institute for Scientific and Medical Research, Yaoundé, Cameroon, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
⨯
Cédric B. Chesnais,

Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Writing – review & editing

Affiliation UMI 233, Institut de Recherche pour le Développement, INSERM Unité, Université de Montpellier, Montpellier, France
⨯
Michel Boussinesq

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

Affiliation UMI 233, Institut de Recherche pour le Développement, INSERM Unité, Université de Montpellier, Montpellier, France
⨯

Revisiting the Loa loa microfilaremia thresholds above which serious adverse events may occur with ivermectin treatment

Charlotte Boullé,
Sébastien D. Pion,
Jacques Gardon,
Nathalie Gardon-Wendel,
Joël Fokom Domgue,
Joseph Kamgno,
Cédric B. Chesnais,
Michel Boussinesq

Published: March 28, 2025
https://doi.org/10.1371/journal.pntd.0012957

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Loa loa
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Loiasis
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