Development of a virulent O’nyong’nyong challenge model to determine heterologous protection mediated by a hydrogen peroxide-inactivated chikungunya virus vaccine

• Whitney C. Weber ,

  Contributed equally to this work with: Whitney C. Weber, Zachary J. Streblow

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this work.

  Affiliations Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Zachary J. Streblow ,

  Contributed equally to this work with: Whitney C. Weber, Zachary J. Streblow

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this work.

  Affiliations Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Takeshi F. Andoh,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Michael Denton,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Hans-Peter Raué,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Ian J. Amanna,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Najít Technologies, Inc., Beaverton, Oregon, United States of America

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• Dawn K. Slifka,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Najít Technologies, Inc., Beaverton, Oregon, United States of America

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• Craig N. Kreklywich,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Irene Arduino,

  Roles Formal analysis, Investigation

  Affiliation Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy

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• Gauthami Sulgey,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Magdalene M. Streblow,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Mark T. Heise,

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Mark K. Slifka,

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Daniel N. Streblow

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  * E-mail: streblow@ohsu.edu

  Affiliations Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0002-6828-2492

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