Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomosis

Sabine Grüschow; Pieter C. Steketee; Edith Paxton; Keith R. Matthews; Liam J. Morrison; Malcolm F. White; Finn Grey

doi:10.1371/journal.pntd.0012937

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Open Access

Peer-reviewed

Research Article

Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomosis

Sabine Grüschow ,

Contributed equally to this work with: Sabine Grüschow, Pieter C. Steketee

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation School of Biology, University of St Andrews, St Andrews, United Kingdom
⨯
Pieter C. Steketee ,

Contributed equally to this work with: Sabine Grüschow, Pieter C. Steketee

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
⨯
Edith Paxton,

Roles Investigation

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
⨯
Keith R. Matthews,

Roles Resources, Writing – review & editing

Affiliation Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Liam J. Morrison,

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
⨯
Malcolm F. White ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: mfw2@st-andrews.ac.uk (MFW); fgrey@ed.ac.uk (FG))

Affiliation School of Biology, University of St Andrews, St Andrews, United Kingdom
⨯
Finn Grey

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: mfw2@st-andrews.ac.uk (MFW); fgrey@ed.ac.uk (FG))

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

https://orcid.org/0000-0003-4288-2059

⨯

Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomosis

Sabine Grüschow,
Pieter C. Steketee,
Edith Paxton,
Keith R. Matthews,
Liam J. Morrison,
Malcolm F. White,
Finn Grey

Published: March 17, 2025
https://doi.org/10.1371/journal.pntd.0012937

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