Patient-centric analysis of Orientia tsutsugamushi spatial diversity patterns across Hainan Island, China

Chuanning Tang; Yi Huang; Gaoyu Wang; Liying Xue; Xiaoyuan Hu; Ruoyan Peng; Jiang Du; Jinyan Yang; Yi Niu; Wanxin Deng; Yibo Jia; Yijia Guo; Siqi Chen; Nan Ge; Liyuan Zhang; Fahui Wang; Yongguo Du; Yueping Wang; Long Sun; Jasper Fuk-Woo Chan; Kwok-Yung Yuen; Biao Wu; Feifei Yin

doi:10.1371/journal.pntd.0012909

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Open Access

Peer-reviewed

Research Article

Patient-centric analysis of Orientia tsutsugamushi spatial diversity patterns across Hainan Island, China

Chuanning Tang ,

Contributed equally to this work with: Chuanning Tang, Yi Huang, Gaoyu Wang, Liying Xue

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China

https://orcid.org/0000-0001-5413-6470

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Yi Huang ,

Contributed equally to this work with: Chuanning Tang, Yi Huang, Gaoyu Wang, Liying Xue

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
⨯
Gaoyu Wang ,

Contributed equally to this work with: Chuanning Tang, Yi Huang, Gaoyu Wang, Liying Xue

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
⨯
Liying Xue ,

Contributed equally to this work with: Chuanning Tang, Yi Huang, Gaoyu Wang, Liying Xue

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
⨯
Xiaoyuan Hu,

Roles Methodology, Validation

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
⨯
Ruoyan Peng,

Roles Funding acquisition, Methodology, Validation

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
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Jiang Du,

Roles Conceptualization

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Jinyan Yang,

Roles Data curation, Validation

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
⨯
Yi Niu,

Roles Data curation, Funding acquisition, Software

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
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Wanxin Deng,

Roles Methodology

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
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Yibo Jia,

Roles Resources

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
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Yijia Guo,

Roles Conceptualization

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
⨯
Siqi Chen,

Roles Conceptualization, Funding acquisition, Methodology

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
⨯
Nan Ge,

Roles Methodology

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China
⨯
Liyuan Zhang,

Roles Resources

Affiliation Department of Infectious Diseases, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Fahui Wang,

Roles Resources

Affiliation Department of Infectious Diseases, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Yongguo Du,

Roles Resources

Affiliation Department of Infectious Diseases, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Yueping Wang,

Roles Conceptualization, Resources

Affiliation Department of Infectious Diseases, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Long Sun,

Roles Conceptualization, Resources

Affiliation Department of Infectious Diseases, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Jasper Fuk-Woo Chan,

Roles Conceptualization

Affiliations State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, and Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
⨯
Kwok-Yung Yuen ,

Roles Conceptualization, Supervision

* E-mail: yinfeifeiff@163.com (FY); wubiaohk@qq.com (BW); kyyuen@hku.hk (K-YY)

Affiliations State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, and Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
⨯
Biao Wu ,

Roles Conceptualization, Funding acquisition, Investigation, Supervision

* E-mail: yinfeifeiff@163.com (FY); wubiaohk@qq.com (BW); kyyuen@hku.hk (K-YY)

Affiliations Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China, Hainan Public Health Clinical Center, Haikou, Hainan, China
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[ ... ],
Feifei Yin

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

* E-mail: yinfeifeiff@163.com (FY); wubiaohk@qq.com (BW); kyyuen@hku.hk (K-YY)

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China, Department of Clinical Laboratory, Center for laboratory Medicine, Hainan Women and Children’s Medical Center, Hainan Medical University, Haikou, Hainan, China

https://orcid.org/0000-0001-6195-0614

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Patient-centric analysis of Orientia tsutsugamushi spatial diversity patterns across Hainan Island, China

Chuanning Tang,
Yi Huang,
Gaoyu Wang,
Liying Xue,
Xiaoyuan Hu,
Ruoyan Peng,
Jiang Du,
Jinyan Yang,
Yi Niu,
Wanxin Deng

Published: March 18, 2025
https://doi.org/10.1371/journal.pntd.0012909

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