Impact of cerebrospinal fluid leukocyte infiltration and activated neuroimmune mediators on survival with HIV-associated cryptococcal meningitis

• Samuel Okurut ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: okuruts@gmail.com

  Affiliations Research Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda, Department of Medical Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda

  https://orcid.org/0000-0002-9292-8687

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• David R. Boulware,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Yukari C. Manabe,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Research Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda, Division of Infectious Diseases, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Lillian Tugume,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Research Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda

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• Caleb P. Skipper,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Kenneth Ssebambulidde,

  Roles Data curation, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Research Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda

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• Joshua Rhein,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Abdu K. Musubire,

  Roles Data curation, Formal analysis, Investigation, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Research Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda

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• Andrew Akampurira,

  Roles Data curation, Formal analysis, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Research Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda, Department of Medical Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda

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• Elizabeth C. Okafor,

  Roles Data curation, Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Joseph O. Olobo,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda

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• Edward N. Janoff,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Mucosal and Vaccine Research Program Colorado, Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado, United States of America, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado United States of America

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• David B. Meya,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Research Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda, Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda

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• for ASTRO Trial Team