Mass spectrometry imaging reveals spatial metabolic variation and the crucial role of uridine metabolism in liver injury caused by Schistosoma japonicum

• Qingkai Xue ,

  Contributed equally to this work with: Qingkai Xue, Xiangyu Zhou

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Writing – original draft

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China, Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, China

  ⨯
• Xiangyu Zhou ,

  Contributed equally to this work with: Qingkai Xue, Xiangyu Zhou

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, China

  ⨯
• Yuyan Wang,

  Roles Investigation, Methodology, Software, Validation

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, China, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China

  ⨯
• Yiyun Liu,

  Roles Investigation, Methodology, Software, Validation

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, China, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China

  ⨯
• Xiaojing Li,

  Roles Investigation

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, China, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China

  ⨯
• Chunrong Xiong,

  Roles Methodology

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, China

  ⨯
• Xinjian Liu ,

  Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: Huangyuzheng@jipd.com (YH); liuxinjian@njmu.edu.cn (XL)

  Affiliation Department of Pathogen Biology, Key Laboratory of Antibody Techniques of National Health Commission, Nanjing Medical University, Nanjing, Jiangsu, China

  ⨯
• Yuzheng Huang

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: Huangyuzheng@jipd.com (YH); liuxinjian@njmu.edu.cn (XL)

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, China, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China

  https://orcid.org/0000-0002-8357-8806

  ⨯