Bimodal distributions of anti-Trypanosoma cruzi antibody levels in blood donors are associated with parasite detection and antibody waning in peripheral blood

• Mirta C. Remesar ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mirtaremesar@gmail.com (MCR); sabinoec@gmail.com (ECS)

  Affiliation Centro Regional de Hemoterapia Garrahan, Hospital de Pediatría Prof. Dr. J. P. Garrahan, Ciudad de Buenos Aires, Buenos Aires, Argentina

  https://orcid.org/0000-0002-5656-1144

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• Ester C. Sabino ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mirtaremesar@gmail.com (MCR); sabinoec@gmail.com (ECS)

  Affiliations Laboratório de Parasitología Medica (LIM-46), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil, Departamento de Moléstias Infecciosas e Parasitárias, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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• Lewis F. Buss ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Centre for Academic Primary care, University of Bristol, Bristol, United Kingdom

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• Claudio D. Merlo ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Investigation, Resources, Supervision

  Affiliation Centro Especializado en Hemoterapia, Resistencia, Chaco, Argentina

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• Mónica G. López ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Investigation, Resources

  Affiliation Centro Especializado en Hemoterapia, Resistencia, Chaco, Argentina

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• Sebastián L. Humeres ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Investigation, Resources

  Affiliation Facultad de Ciencias Exactas y Agrimensura, Universidad Nacional del Nordeste, Ciudad de Corrientes, Corrientes, Argentina

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• Héctor A. Pavón ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Investigation, Resources

  Affiliation Centro Especializado en Hemoterapia, Resistencia, Chaco, Argentina

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• Clara Di Germanio ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Vitalant Research Institute, San Francisco, California, United States of America

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• Sonia Bakkour Coco ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Vitalant Research Institute, San Francisco, California, United States of America

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• Léa C. Oliveira-da Silva ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Laboratório de Parasitología Medica (LIM-46), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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• Marcelo Martins Pinto Filho ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Telehealth Center and Cardiology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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• Antonio L. Ribeiro ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Supervision, Writing – review & editing

  Affiliation Telehealth Center and Cardiology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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• Michael P. Busch ,

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Vitalant Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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• Ana E. del Pozo

  Contributed equally to this work with: Mirta C. Remesar, Ester C. Sabino, Lewis F. Buss, Claudio D. Merlo, Mónica G. López, Sebastián L. Humeres, Héctor A. Pavón, Clara Di Germanio, Sonia Bakkour Coco, Léa C. Oliveira-da Silva, Marcelo Martins Pinto Filho, Antonio L. Ribeiro, Michael P. Busch, Ana E. del Pozo

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Centro Regional de Hemoterapia Garrahan, Hospital de Pediatría Prof. Dr. J. P. Garrahan, Ciudad de Buenos Aires, Buenos Aires, Argentina, Chaco Province Blood Program Consultant, Ministerio de Salud de la Provincia de Chaco, Resistencia, Chaco, Argentina

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