Extracellular vesicles of Clonorchis sinensis promote the malignant phenotypes of cholangiocarcinoma via NF-κB/EMT axis

Xiaowen Pan; Qing He; Yingxuan Yin; Anyuan Xu; Aoxun Wu; Xueqing Yi; Zifeng Zhong; Yinjuan Wu; Xuerong Li

doi:10.1371/journal.pntd.0012545

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Open Access

Peer-reviewed

Research Article

Extracellular vesicles of Clonorchis sinensis promote the malignant phenotypes of cholangiocarcinoma via NF-κB/EMT axis

Xiaowen Pan ,

Contributed equally to this work with: Xiaowen Pan, Qing He

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory for Tropical Diseases Control of Ministry of Education, Sun Yat-sen University, Guangzhou, China, Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China, China Atomic Energy Authority Center of Excellence on Nuclear Technology Applications for Insect Control, Beijing, China
⨯
Qing He ,

Contributed equally to this work with: Xiaowen Pan, Qing He

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory for Tropical Diseases Control of Ministry of Education, Sun Yat-sen University, Guangzhou, China, Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China, China Atomic Energy Authority Center of Excellence on Nuclear Technology Applications for Insect Control, Beijing, China, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
⨯
Yingxuan Yin,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory for Tropical Diseases Control of Ministry of Education, Sun Yat-sen University, Guangzhou, China, Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China, China Atomic Energy Authority Center of Excellence on Nuclear Technology Applications for Insect Control, Beijing, China, Department of Blood Transfusion, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Anyuan Xu,

Roles Writing – review & editing

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory for Tropical Diseases Control of Ministry of Education, Sun Yat-sen University, Guangzhou, China, Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China, China Atomic Energy Authority Center of Excellence on Nuclear Technology Applications for Insect Control, Beijing, China
⨯
Aoxun Wu,

Roles Writing – review & editing

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory for Tropical Diseases Control of Ministry of Education, Sun Yat-sen University, Guangzhou, China, Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China, China Atomic Energy Authority Center of Excellence on Nuclear Technology Applications for Insect Control, Beijing, China
⨯
Xueqing Yi,

Roles Writing – review & editing

Affiliation Department of Basic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
⨯
Zifeng Zhong,

Roles Writing – review & editing

Affiliation Department of Basic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
⨯
Yinjuan Wu ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Validation, Writing – review & editing

* E-mail: wuyinjuan@mail.sysu.edu.cn (YW); xuerong2@mail.sysu.edu.cn (XL)

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory for Tropical Diseases Control of Ministry of Education, Sun Yat-sen University, Guangzhou, China, Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China, China Atomic Energy Authority Center of Excellence on Nuclear Technology Applications for Insect Control, Beijing, China
⨯
Xuerong Li

Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – review & editing

* E-mail: wuyinjuan@mail.sysu.edu.cn (YW); xuerong2@mail.sysu.edu.cn (XL)

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory for Tropical Diseases Control of Ministry of Education, Sun Yat-sen University, Guangzhou, China, Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China, China Atomic Energy Authority Center of Excellence on Nuclear Technology Applications for Insect Control, Beijing, China

https://orcid.org/0000-0002-5518-1617

⨯

Extracellular vesicles of Clonorchis sinensis promote the malignant phenotypes of cholangiocarcinoma via NF-κB/EMT axis

Xiaowen Pan,
Qing He,
Yingxuan Yin,
Anyuan Xu,
Aoxun Wu,
Xueqing Yi,
Zifeng Zhong,
Yinjuan Wu,
Xuerong Li

Published: October 28, 2024
https://doi.org/10.1371/journal.pntd.0012545

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