Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes

Md Mukthar Mia; Idrees Mehraj Allaie; Xuejin Zhang; Kun Li; Shahbaz M. Khan; Saki Kadotani; William H. Witola

doi:10.1371/journal.pntd.0012473

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Open Access

Peer-reviewed

Research Article

Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes

Md Mukthar Mia,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America
⨯
Idrees Mehraj Allaie,

Roles Investigation, Methodology

Affiliation Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America
⨯
Xuejin Zhang,

Roles Investigation, Methodology

Affiliation Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America
⨯
Kun Li,

Roles Investigation, Methodology

Affiliations Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America, Institute of Traditional Chinese Veterinary Medicine, MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
⨯
Shahbaz M. Khan,

Roles Investigation, Visualization

Affiliation Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America
⨯
Saki Kadotani,

Roles Resources

Affiliation Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America
⨯
William H. Witola

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: whwit35@illinois.edu

Affiliation Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America

https://orcid.org/0000-0002-2308-0539

⨯

Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes

Md Mukthar Mia,
Idrees Mehraj Allaie,
Xuejin Zhang,
Kun Li,
Shahbaz M. Khan,
Saki Kadotani,
William H. Witola

Published: August 30, 2024
https://doi.org/10.1371/journal.pntd.0012473

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Dopamine
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Methyltransferases
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Catecholamines
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Protein structure prediction
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Enzyme inhibitors
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Nematode infections
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Enzymes
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Protein structure
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