CRISPR-Cas9 knockout of membrane-bound alkaline phosphatase or cadherin does not confer resistance to Cry toxins in Aedes aegypti

Sabino Pacheco; Adrián S. Gallegos; Ángel E. Peláez-Aguilar; Jorge Sánchez; Isabel Gómez; Mario Soberón; Alejandra Bravo

doi:10.1371/journal.pntd.0012256

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Open Access

Peer-reviewed

Research Article

CRISPR-Cas9 knockout of membrane-bound alkaline phosphatase or cadherin does not confer resistance to Cry toxins in Aedes aegypti

Sabino Pacheco ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

* E-mail: sabino.pacheco@ibt.unam.mx

Affiliation Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico

https://orcid.org/0000-0002-0208-0046

⨯
Adrián S. Gallegos,

Roles Investigation

Affiliation Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico
⨯
Ángel E. Peláez-Aguilar,

Roles Investigation

Affiliation Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico
⨯
Jorge Sánchez,

Roles Investigation

Affiliation Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico
⨯
Isabel Gómez,

Roles Formal analysis, Investigation

Affiliation Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico
⨯
Mario Soberón,

Roles Writing – review & editing

Affiliation Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico
⨯
Alejandra Bravo

Roles Funding acquisition, Writing – review & editing

Affiliation Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico
⨯

CRISPR-Cas9 knockout of membrane-bound alkaline phosphatase or cadherin does not confer resistance to Cry toxins in Aedes aegypti

Sabino Pacheco,
Adrián S. Gallegos,
Ángel E. Peláez-Aguilar,
Jorge Sánchez,
Isabel Gómez,
Mario Soberón,
Alejandra Bravo

Published: June 13, 2024
https://doi.org/10.1371/journal.pntd.0012256

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Toxins
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Larvae
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Aedes aegypti
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Homozygosity
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Polymerase chain reaction
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