The NS1 protein of contemporary West African Zika virus potentiates viral replication and reduces innate immune activation

• Dana Machmouchi,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion, INSERM U1187, CNRS 9192, IRD 249, Plateforme Technologique CYROI, Sainte-Clotilde, La Réunion, France

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• Marie-Pierre Courageot,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation UR7506-BioSpect, Université de Reims Champagne-Ardennes, Reims, France

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• Eva Ogire,

  Roles Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Current address: Centre International de Recherche en Infectiologie, Lyon, France

  Affiliation Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion, INSERM U1187, CNRS 9192, IRD 249, Plateforme Technologique CYROI, Sainte-Clotilde, La Réunion, France

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• Lars Redecke,

  Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing

  Affiliations University of Luebeck, Institute of Biochemistry, Luebeck, Germany, Deutsches Elektronen Synchrotron (DESY), Photon Science, Hamburg, Germany

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• Alain Kohl,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

  Affiliations Centre for Neglected Tropical Diseases, Departments of Tropical Disease Biology and Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, MRC-University of Glasgow Centre for Virus Research, Glasgow, United-Kingdom

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• Philippe Desprès ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: philippe.despres@univ-reunion.fr (PD); marjolaine.roche@univ-reunion.fr (MR)

  Affiliation Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion, INSERM U1187, CNRS 9192, IRD 249, Plateforme Technologique CYROI, Sainte-Clotilde, La Réunion, France

  https://orcid.org/0000-0001-8926-4050

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• Marjolaine Roche

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: philippe.despres@univ-reunion.fr (PD); marjolaine.roche@univ-reunion.fr (MR)

  Affiliation Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion, INSERM U1187, CNRS 9192, IRD 249, Plateforme Technologique CYROI, Sainte-Clotilde, La Réunion, France

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