Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study

Anuradha Rajamanickam; Bindu Dasan; Saravanan Munisankar; Sujatha Nott; Pradeep A. Menon; Fayaz Ahamed Shaik; Ponnuraja Chinnaiyan; Thomas B. Nutman; Subash Babu

doi:10.1371/journal.pntd.0012048

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Open Access

Peer-reviewed

Research Article

Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study

Anuradha Rajamanickam ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: anuradha@icerindia.org

Affiliation NIH-NIAID-International Center for Excellence in Research, Chennai, India

https://orcid.org/0000-0002-8143-5502

⨯
Bindu Dasan,

Roles Investigation, Methodology

Affiliation NIH-NIAID-International Center for Excellence in Research, Chennai, India
⨯
Saravanan Munisankar,

Roles Investigation, Methodology

Affiliation NIH-NIAID-International Center for Excellence in Research, Chennai, India
⨯
Sujatha Nott,

Roles Resources, Visualization

Affiliation Infectious Diseases, Dignity Health, Chandler, Arizona, United States of America
⨯
Pradeep A. Menon,

Roles Resources

Affiliation National Institute for Research in Tuberculosis, Chennai, India
⨯
Fayaz Ahamed Shaik,

Roles Data curation, Formal analysis

Affiliation NIH-NIAID-International Center for Excellence in Research, Chennai, India
⨯
Ponnuraja Chinnaiyan,

Roles Data curation, Formal analysis, Validation

Affiliation National Institute for Research in Tuberculosis, Chennai, India
⨯
Thomas B. Nutman,

Roles Funding acquisition, Resources, Software, Writing – review & editing

Affiliation Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Subash Babu

Roles Conceptualization, Funding acquisition, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

Affiliations NIH-NIAID-International Center for Excellence in Research, Chennai, India, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study

Anuradha Rajamanickam,
Bindu Dasan,
Saravanan Munisankar,
Sujatha Nott,
Pradeep A. Menon,
Fayaz Ahamed Shaik,
Ponnuraja Chinnaiyan,
Thomas B. Nutman,
Subash Babu

Published: April 2, 2024
https://doi.org/10.1371/journal.pntd.0012048

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Diabetes mellitus
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Complement system
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Regulatory proteins
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Helminth infections
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Type 2 diabetes
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Principal component analysis
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Lectins
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