Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity

Maikel Izquierdo; De Lin; Sandra O’Neill; Lauren A. Webster; Christy Paterson; John Thomas; Mirtha Elisa Aguado; Enrique Colina Araújo; Daniel Alpízar-Pedraza; Halimatu Joji; Lorna MacLean; Anthony Hope; David W. Gray; Martin Zoltner; Mark C. Field; Jorge González-Bacerio; Manu De Rycker

doi:10.1371/journal.pntd.0011956

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Open Access

Peer-reviewed

Research Article

Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity

Maikel Izquierdo,

Roles Data curation, Formal analysis, Investigation

Affiliation Centre for Protein Studies, Faculty of Biology, University of Havana, La Habana, Cuba
⨯
De Lin,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom
⨯
Sandra O’Neill,

Roles Investigation, Methodology

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom
⨯
Lauren A. Webster,

Roles Formal analysis, Resources

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom
⨯
Christy Paterson,

Roles Data curation, Formal analysis, Investigation

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom
⨯
John Thomas,

Roles Data curation, Formal analysis, Investigation

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom
⨯
Mirtha Elisa Aguado,

Roles Data curation, Formal analysis, Investigation

Affiliation Centre for Protein Studies, Faculty of Biology, University of Havana, La Habana, Cuba
⨯
Enrique Colina Araújo,

Roles Data curation, Formal analysis, Investigation, Software, Visualization

Affiliation Department of Biochemistry, Faculty of Biology, University of Havana, La Habana, Cuba
⨯
Daniel Alpízar-Pedraza,

Roles Conceptualization, Data curation, Formal analysis, Visualization

Affiliation Centre for Pharmaceuticals Research and Development, La Habana, Cuba
⨯
Halimatu Joji,

Roles Data curation, Formal analysis, Investigation

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom
⨯
Lorna MacLean,

Roles Data curation, Project administration, Supervision, Validation

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom
⨯
Anthony Hope,

Roles Conceptualization, Methodology

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom
⨯
David W. Gray,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom
⨯
Martin Zoltner,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom, Department of Parasitology, Faculty of Science, Charles University in Prague, Biocev, Vestec, Czech Republic
⨯
Mark C. Field,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliations School of Life Sciences, University of Dundee, Dundee, United Kingdom, Biology Centre, Czech Academy of Sciences, Institute of Parasitology, České Budějovice, Czech Republic
⨯
Jorge González-Bacerio ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: jogoba@fbio.uh.cu (JGB); m.derycker@dundee.ac.uk (MDR)

Affiliations Centre for Protein Studies, Faculty of Biology, University of Havana, La Habana, Cuba, Department of Biochemistry, Faculty of Biology, University of Havana, La Habana, Cuba
⨯
[ ... ],
Manu De Rycker

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: jogoba@fbio.uh.cu (JGB); m.derycker@dundee.ac.uk (MDR)

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom

https://orcid.org/0000-0002-3171-3519

⨯
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Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity

Maikel Izquierdo,
De Lin,
Sandra O’Neill,
Lauren A. Webster,
Christy Paterson,
John Thomas,
Mirtha Elisa Aguado,
Enrique Colina Araújo,
Daniel Alpízar-Pedraza,
Halimatu Joji

Published: February 15, 2024
https://doi.org/10.1371/journal.pntd.0011956

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