MicroRNA-194 regulates parasitic load and IL-1β-dependent nitric oxide production in the peripheral blood mononuclear cells of dogs with leishmaniasis

Sidnei Ferro Costa; Matheus Fujimura Soares; Jaqueline Poleto Bragato; Marilene Oliveira dos Santos; Gabriela Torres Rebech; Jéssica Henrique de Freitas; Valéria Marçal Felix de Lima

doi:10.1371/journal.pntd.0011789

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Open Access

Peer-reviewed

Research Article

MicroRNA-194 regulates parasitic load and IL-1β-dependent nitric oxide production in the peripheral blood mononuclear cells of dogs with leishmaniasis

Sidnei Ferro Costa ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: sidnei-fcosta@hotmail.com (SFC); valeria.lima@unesp.br (VMFL)

Affiliation Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil
⨯
Matheus Fujimura Soares,

Roles Methodology, Software

Affiliation Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil
⨯
Jaqueline Poleto Bragato,

Roles Methodology

Affiliation Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil
⨯
Marilene Oliveira dos Santos,

Roles Methodology

Affiliation Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil
⨯
Gabriela Torres Rebech,

Roles Methodology

Affiliation Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil
⨯
Jéssica Henrique de Freitas,

Roles Methodology

Affiliation Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil
⨯
Valéria Marçal Felix de Lima

Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – review & editing

* E-mail: sidnei-fcosta@hotmail.com (SFC); valeria.lima@unesp.br (VMFL)

Affiliation Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil

https://orcid.org/0000-0002-0954-5045

⨯

MicroRNA-194 regulates parasitic load and IL-1β-dependent nitric oxide production in the peripheral blood mononuclear cells of dogs with leishmaniasis

Sidnei Ferro Costa,
Matheus Fujimura Soares,
Jaqueline Poleto Bragato,
Marilene Oliveira dos Santos,
Gabriela Torres Rebech,
Jéssica Henrique de Freitas,
Valéria Marçal Felix de Lima

Published: January 19, 2024
https://doi.org/10.1371/journal.pntd.0011789

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Dogs
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Leishmaniasis
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Parasitic diseases
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Cytokines
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Transfection
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Transcription factors
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MicroRNAs
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Nitric oxide
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