Vaccination against the HDL receptor of S. japonicum inhibits egg embryonation and prevents fatal hepatic complication in rabbit model

Jifeng Zhu; Lina Zhang; Zechao Xue; Zilüe Li; Chun Wang; Fanyan Chen; Yalin Li; Yang Dai; Yonghua Zhou; Sha Zhou; Xiaojun Chen; Kuniko Okumura-Noji; Rui Lu; Shinji Yokoyama; Chuan Su

doi:10.1371/journal.pntd.0011749

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Open Access

Peer-reviewed

Research Article

Vaccination against the HDL receptor of S. japonicum inhibits egg embryonation and prevents fatal hepatic complication in rabbit model

Jifeng Zhu ,

Contributed equally to this work with: Jifeng Zhu, Lina Zhang

Roles Data curation, Methodology, Project administration, Software, Writing – original draft

Affiliations National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Lina Zhang ,

Contributed equally to this work with: Jifeng Zhu, Lina Zhang

Roles Data curation, Investigation, Methodology, Software

Affiliations Department of Blood Transfusion, Henan Provincial People’s Hospital, Zhengzhou, Henan, China, Department of Blood Transfusion of Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan, China
⨯
Zechao Xue,

Roles Investigation

Affiliations National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Zilüe Li,

Roles Investigation

Affiliations National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Chun Wang,

Roles Investigation

Affiliations National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Fanyan Chen,

Roles Investigation

Affiliations National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yalin Li,

Roles Investigation

Affiliations National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yang Dai,

Roles Investigation

Affiliation Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China
⨯
Yonghua Zhou,

Roles Investigation

Affiliation Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China
⨯
Sha Zhou,

Roles Investigation

Affiliations National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Xiaojun Chen,

Roles Investigation

Affiliations National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Kuniko Okumura-Noji,

Roles Investigation

Affiliation Food and Nutritional Sciences, Chubu University, Kasugai, Japan
⨯
Rui Lu,

Roles Investigation

Affiliation Food and Nutritional Sciences, Chubu University, Kasugai, Japan
⨯
Shinji Yokoyama ,

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: syokoyam@isc.chubu.ac.jp (SY); chuansu@njmu.edu.cn (CS)

Affiliation Food and Nutritional Sciences, Chubu University, Kasugai, Japan
⨯
Chuan Su

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

* E-mail: syokoyam@isc.chubu.ac.jp (SY); chuansu@njmu.edu.cn (CS)

Affiliations National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China

https://orcid.org/0000-0002-8271-2428

⨯

Vaccination against the HDL receptor of S. japonicum inhibits egg embryonation and prevents fatal hepatic complication in rabbit model

Jifeng Zhu,
Lina Zhang,
Zechao Xue,
Zilüe Li,
Chun Wang,
Fanyan Chen,
Yalin Li,
Yang Dai,
Yonghua Zhou,
Sha Zhou

Published: November 29, 2023
https://doi.org/10.1371/journal.pntd.0011749

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