Mining host candidate regulators of schistosomiasis-induced liver fibrosis in response to artesunate therapy through transcriptomics approach

Yajie Yuan; Xinyue Lv; Yahan Wu; Youhong Weng; Fangwei Dai; Haojie Ding; Riping Chen; Bin Zheng; Wenxia Zhao; Qunbo Tong; Jianzu Ding; Di Lou; Yunru Lai; Xiaofeng Chu; Longyou Zhao; Shaohong Lu; Qingming Kong

doi:10.1371/journal.pntd.0011626

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Open Access

Peer-reviewed

Research Article

Mining host candidate regulators of schistosomiasis-induced liver fibrosis in response to artesunate therapy through transcriptomics approach

Yajie Yuan ,

Contributed equally to this work with: Yajie Yuan, Xinyue Lv

Roles Conceptualization, Data curation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province, School of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, China, Department of Pathogen Biology, School of Basic Medicine, Nanjing Medical University, Nanjing, China
⨯
Xinyue Lv ,

Contributed equally to this work with: Yajie Yuan, Xinyue Lv

Roles Data curation, Visualization, Writing – review & editing

Affiliation Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province, School of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, China
⨯
Yahan Wu,

Roles Validation

Affiliation Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province, School of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, China
⨯
Youhong Weng,

Roles Validation

Affiliation Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province, School of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, China
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Fangwei Dai,

Roles Funding acquisition, Resources

Affiliation Zhejiang Key Laboratory of Experimental Animal and Safety Evaluation, Hangzhou Medical College, Zhejiang Academy of Medical Sciences, Hangzhou, China
⨯
Haojie Ding,

Roles Funding acquisition, Validation

Affiliation School of Basic Medicine and Forensics, Key Laboratory of Bio-tech Vaccine of Zhejiang Province, Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College, Hangzhou, China
⨯
Riping Chen,

Roles Validation

Affiliation School of Public Health, Hangzhou Medical College, Zhejiang Academy of Medical Sciences, Hangzhou, China
⨯
Bin Zheng,

Roles Validation

Affiliation School of Basic Medicine and Forensics, Key Laboratory of Bio-tech Vaccine of Zhejiang Province, Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College, Hangzhou, China
⨯
Wenxia Zhao,

Roles Methodology

Affiliation School of Public Health, Hangzhou Medical College, Zhejiang Academy of Medical Sciences, Hangzhou, China
⨯
Qunbo Tong,

Roles Methodology

Affiliation School of Basic Medicine and Forensics, Key Laboratory of Bio-tech Vaccine of Zhejiang Province, Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College, Hangzhou, China
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Jianzu Ding,

Roles Methodology

Affiliation School of Basic Medicine and Forensics, Key Laboratory of Bio-tech Vaccine of Zhejiang Province, Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College, Hangzhou, China
⨯
Di Lou,

Roles Methodology

Affiliation School of Basic Medicine and Forensics, Key Laboratory of Bio-tech Vaccine of Zhejiang Province, Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College, Hangzhou, China
⨯
Yunru Lai,

Roles Resources

Affiliation Department of Laboratory Medicine, Lishui Second People’s Hospital Affiliated to Wenzhou Medical University, Lishui, China
⨯
Xiaofeng Chu,

Roles Methodology

Affiliation Zhejiang Key Laboratory of Experimental Animal and Safety Evaluation, Hangzhou Medical College, Zhejiang Academy of Medical Sciences, Hangzhou, China
⨯
Longyou Zhao ,

Roles Funding acquisition, Resources, Supervision

* E-mail: zly8897@126.com (LZ); llsshh2003@163.com (SL); qmkong_1025@163.com (QK)

Affiliation Department of Laboratory Medicine, Lishui Second People’s Hospital Affiliated to Wenzhou Medical University, Lishui, China
⨯
Shaohong Lu ,

Roles Funding acquisition, Supervision

* E-mail: zly8897@126.com (LZ); llsshh2003@163.com (SL); qmkong_1025@163.com (QK)

Affiliation School of Basic Medicine and Forensics, Key Laboratory of Bio-tech Vaccine of Zhejiang Province, Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College, Hangzhou, China
⨯
[ ... ],
Qingming Kong

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: zly8897@126.com (LZ); llsshh2003@163.com (SL); qmkong_1025@163.com (QK)

Affiliations Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province, School of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, China, School of Basic Medicine and Forensics, Key Laboratory of Bio-tech Vaccine of Zhejiang Province, Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College, Hangzhou, China

https://orcid.org/0000-0001-5928-1116

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Mining host candidate regulators of schistosomiasis-induced liver fibrosis in response to artesunate therapy through transcriptomics approach

Yajie Yuan,
Xinyue Lv,
Yahan Wu,
Youhong Weng,
Fangwei Dai,
Haojie Ding,
Riping Chen,
Bin Zheng,
Wenxia Zhao,
Qunbo Tong

Published: September 29, 2023
https://doi.org/10.1371/journal.pntd.0011626

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