Single-cell sequencing analysis reveals development and differentiation trajectory of Schwann cells manipulated by M. leprae

Shanshan Ma; Zihao Mi; Zhenzhen Wang; Lele Sun; Tingting Liu; Peidian Shi; Chuan Wang; Xiaotong Xue; Wenjie Chen; Zhe Wang; Yueqian Yu; Yuan Zhang; Fangfang Bao; Na Wang; Honglei Wang; Qianqian Xia; Hong Liu; Yonghu Sun; Furen Zhang

doi:10.1371/journal.pntd.0011477

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Open Access

Peer-reviewed

Research Article

Single-cell sequencing analysis reveals development and differentiation trajectory of Schwann cells manipulated by M. leprae

Shanshan Ma,

Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China

https://orcid.org/0000-0003-4431-0118

⨯
Zihao Mi,

Roles Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Zhenzhen Wang,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Lele Sun,

Roles Investigation, Methodology, Visualization

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Tingting Liu,

Roles Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Peidian Shi,

Roles Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Chuan Wang,

Roles Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Xiaotong Xue,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Wenjie Chen,

Roles Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Zhe Wang,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Yueqian Yu,

Roles Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Yuan Zhang,

Roles Investigation, Methodology, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Fangfang Bao,

Roles Funding acquisition, Investigation, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Na Wang,

Roles Funding acquisition, Investigation, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Honglei Wang,

Roles Funding acquisition, Investigation, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Qianqian Xia,

Roles Funding acquisition, Investigation, Validation

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Hong Liu,

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Yonghu Sun ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: suohandong@126.com (YS); zhangfuren@hotmail.com (FZ)

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
[ ... ],
Furen Zhang

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: suohandong@126.com (YS); zhangfuren@hotmail.com (FZ)

Affiliation Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China

https://orcid.org/0000-0002-3383-1973

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Single-cell sequencing analysis reveals development and differentiation trajectory of Schwann cells manipulated by M. leprae

Shanshan Ma,
Zihao Mi,
Zhenzhen Wang,
Lele Sun,
Tingting Liu,
Peidian Shi,
Chuan Wang,
Xiaotong Xue,
Wenjie Chen,
Zhe Wang

Published: July 21, 2023
https://doi.org/10.1371/journal.pntd.0011477

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Mycobacterium leprae
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Cell differentiation
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RNA sequencing
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Schwann cells
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