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Open Access
Peer-reviewed
Research Article
Schistosome egg antigen stimulates the secretion of miR-33-carrying extracellular vesicles from macrophages to promote hepatic stellate cell activation and liver fibrosis in schistosomiasis
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Xin Qi ,
Contributed equally to this work with: Xin Qi, Yanan Pu
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Yanan Pu ,
Contributed equally to this work with: Xin Qi, Yanan Pu
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft
Affiliations Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Outpatient & Emergency Management, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
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Fanyan Chen,
Roles Investigation, Methodology
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Liyang Dong,
Roles Investigation, Methodology
Affiliations Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Nuclear Medicine, the Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
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Yongbin Ma,
Roles Investigation, Methodology
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Junling Wang,
Roles Investigation, Methodology
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Guo Yin,
Roles Investigation, Methodology
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Di Lu,
Roles Investigation, Methodology
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Xiaojun Chen,
Roles Conceptualization, Methodology
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Jifeng Zhu,
Roles Conceptualization, Methodology
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Yalin Li,
Roles Investigation, Methodology, Resources
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Sha Zhou ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: shazhou@njmu.edu.cn (SZ); chuansu@njmu.edu.cn (CS)
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Chuan Su
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: shazhou@njmu.edu.cn (SZ); chuansu@njmu.edu.cn (CS)
Affiliation Center for Global Health, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, China
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Schistosome egg antigen stimulates the secretion of miR-33-carrying extracellular vesicles from macrophages to promote hepatic stellate cell activation and liver fibrosis in schistosomiasis
- Xin Qi,
- Yanan Pu,
- Fanyan Chen,
- Liyang Dong,
- Yongbin Ma,
- Junling Wang,
- Guo Yin,
- Di Lu,
- Xiaojun Chen,
- Jifeng Zhu
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- Published: May 30, 2023
- https://doi.org/10.1371/journal.pntd.0011385