Genomic bacterial load associated with bacterial genotypes and clinical characteristics in patients with scrub typhus in Hainan Island, Southern China

Gaoyu Wang; Ruijia Fu; Liyuan Zhang; Liying Xue; Abdullah Y. Al-Mahdi; Xiaofei Xie; Aiping Qin; Chuanning Tang; Jiang Du; Yi Huang; Yueping Wang; Jian Su; Shengkai Huang; Ruoyan Peng; Zhe Lu; Jing An; Changjia Sun; Hua Yang; Changhua He; Kwok-Yung Yuen; Jasper Fuk-Woo Chan; Yongguo Du; Meifang Xiao; Long Sun; Feifei Yin

doi:10.1371/journal.pntd.0011243

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Open Access

Peer-reviewed

Research Article

Genomic bacterial load associated with bacterial genotypes and clinical characteristics in patients with scrub typhus in Hainan Island, Southern China

Gaoyu Wang ,

Contributed equally to this work with: Gaoyu Wang, Ruijia Fu, Liyuan Zhang, Liying Xue

Roles Formal analysis, Funding acquisition, Methodology, Software, Writing – original draft

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Department of Clinical Laboratory, Center for Laboratory Medicine, Hainan Women and Children’s Medical Center, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China
⨯
Ruijia Fu ,

Contributed equally to this work with: Gaoyu Wang, Ruijia Fu, Liyuan Zhang, Liying Xue

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliation Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
⨯
Liyuan Zhang ,

Contributed equally to this work with: Gaoyu Wang, Ruijia Fu, Liyuan Zhang, Liying Xue

Roles Funding acquisition, Investigation, Methodology, Resources

Affiliation Department of Infectious Disease, the Second Affiliated Hospital of Hainan Medical University, Haikou, China
⨯
Liying Xue ,

Contributed equally to this work with: Gaoyu Wang, Ruijia Fu, Liyuan Zhang, Liying Xue

Roles Investigation, Methodology

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China
⨯
Abdullah Y. Al-Mahdi,

Roles Project administration

Affiliation Faculty of medicine, Lincoln University College, Petaling Jaya, Malaysia
⨯
Xiaofei Xie,

Roles Investigation, Methodology

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China
⨯
Aiping Qin,

Roles Methodology

Affiliation State Key Laboratory of Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
⨯
Chuanning Tang,

Roles Data curation, Formal analysis, Funding acquisition, Software

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China
⨯
Jiang Du,

Roles Data curation, Formal analysis, Software

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China
⨯
Yi Huang,

Roles Data curation, Formal analysis, Funding acquisition, Software

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China
⨯
Yueping Wang,

Roles Investigation, Methodology

Affiliation Department of Infectious Disease, the First affiliated Hospital of Hainan Medical University, Haikou, China
⨯
Jian Su,

Roles Investigation, Methodology

Affiliation Department of Infectious Disease, the First affiliated Hospital of Hainan Medical University, Haikou, China
⨯
Shengkai Huang,

Roles Investigation, Methodology

Affiliation Department of Infectious Disease, the First affiliated Hospital of Hainan Medical University, Haikou, China
⨯
Ruoyan Peng,

Roles Funding acquisition, Investigation, Methodology

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China
⨯
Zhe Lu,

Roles Investigation, Methodology

Affiliation Department of Clinical Laboratory, Center for Laboratory Medicine, Hainan Women and Children’s Medical Center, Haikou, China
⨯
Jing An,

Roles Investigation, Methodology

Affiliation Department of Clinical Laboratory, Center for Laboratory Medicine, Hainan Women and Children’s Medical Center, Haikou, China
⨯
Changjia Sun,

Roles Investigation, Methodology

Affiliation Department of Clinical Laboratory, Center for Laboratory Medicine, Hainan Women and Children’s Medical Center, Haikou, China
⨯
Hua Yang,

Roles Investigation, Methodology

Affiliation Department of Clinical Laboratory, Center for Laboratory Medicine, Hainan Women and Children’s Medical Center, Haikou, China
⨯
Changhua He,

Roles Funding acquisition, Investigation, Methodology

Affiliation Hainan Center for Disease Control and Prevention, Haikou, China
⨯
Kwok-Yung Yuen,

Roles Conceptualization, Project administration, Supervision, Validation

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Jasper Fuk-Woo Chan,

Roles Conceptualization, Funding acquisition, Supervision, Validation

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Yongguo Du ,

Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing

* E-mail: duyongguo@163.com (YD); xiaomeifang2006@hotmail.com (MX); hysunlong@163.com (LS); yinfeifeiff@163.com (FY)

¶‡ YD, MX, LS and FY also contributed equally to this work.

Affiliation Department of Infectious Disease, the Second Affiliated Hospital of Hainan Medical University, Haikou, China
⨯
Meifang Xiao ,

Roles Conceptualization, Funding acquisition, Resources, Validation, Writing – original draft

* E-mail: duyongguo@163.com (YD); xiaomeifang2006@hotmail.com (MX); hysunlong@163.com (LS); yinfeifeiff@163.com (FY)

¶‡ YD, MX, LS and FY also contributed equally to this work.

Affiliations Department of Clinical Laboratory, Center for Laboratory Medicine, Hainan Women and Children’s Medical Center, Haikou, China, Faculty of medicine, Lincoln University College, Petaling Jaya, Malaysia
⨯
Long Sun ,

Roles Conceptualization, Resources, Writing – review & editing

* E-mail: duyongguo@163.com (YD); xiaomeifang2006@hotmail.com (MX); hysunlong@163.com (LS); yinfeifeiff@163.com (FY)

¶‡ YD, MX, LS and FY also contributed equally to this work.

Affiliation Department of Infectious Disease, the First affiliated Hospital of Hainan Medical University, Haikou, China
⨯
[ ... ],
Feifei Yin

Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: duyongguo@163.com (YD); xiaomeifang2006@hotmail.com (MX); hysunlong@163.com (LS); yinfeifeiff@163.com (FY)

¶‡ YD, MX, LS and FY also contributed equally to this work.

Affiliations Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, Department of Clinical Laboratory, Center for Laboratory Medicine, Hainan Women and Children’s Medical Center, Haikou, China, Academician Workstation of Hainan Province, Hainan Medical University; Haikou, China

https://orcid.org/0000-0001-6195-0614

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Genomic bacterial load associated with bacterial genotypes and clinical characteristics in patients with scrub typhus in Hainan Island, Southern China

Gaoyu Wang,
Ruijia Fu,
Liyuan Zhang,
Liying Xue,
Abdullah Y. Al-Mahdi,
Xiaofei Xie,
Aiping Qin,
Chuanning Tang,
Jiang Du,
Yi Huang

Published: April 21, 2023
https://doi.org/10.1371/journal.pntd.0011243

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