On-target inhibition of Cryptosporidium parvum by nitazoxanide (NTZ) and paclitaxel (PTX) validated using a novel MDR1-transgenic host cell model and algorithms to quantify the effect on the parasite target

Bo Yang; Yueyang Yan; Dongqiang Wang; Ying Zhang; Jigang Yin; Guan Zhu

doi:10.1371/journal.pntd.0011217

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Open Access

Peer-reviewed

Research Article

On-target inhibition of Cryptosporidium parvum by nitazoxanide (NTZ) and paclitaxel (PTX) validated using a novel MDR1-transgenic host cell model and algorithms to quantify the effect on the parasite target

Bo Yang ,

Contributed equally to this work with: Bo Yang, Yueyang Yan

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of the Ministry of Education, the Institute of Zoonosis, and the College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Yueyang Yan ,

Contributed equally to this work with: Bo Yang, Yueyang Yan

Roles Formal analysis, Investigation, Software, Visualization

Affiliation State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of the Ministry of Education, the Institute of Zoonosis, and the College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Dongqiang Wang,

Roles Investigation, Methodology

Affiliation State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of the Ministry of Education, the Institute of Zoonosis, and the College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Ying Zhang,

Roles Investigation

Affiliation State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of the Ministry of Education, the Institute of Zoonosis, and the College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Jigang Yin,

Roles Funding acquisition, Investigation

Affiliation State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of the Ministry of Education, the Institute of Zoonosis, and the College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Guan Zhu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: cryptosporida@gmail.com

Affiliation State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of the Ministry of Education, the Institute of Zoonosis, and the College of Veterinary Medicine, Jilin University, Changchun, China

https://orcid.org/0000-0003-3888-0659

⨯

On-target inhibition of Cryptosporidium parvum by nitazoxanide (NTZ) and paclitaxel (PTX) validated using a novel MDR1-transgenic host cell model and algorithms to quantify the effect on the parasite target

Bo Yang,
Yueyang Yan,
Dongqiang Wang,
Ying Zhang,
Jigang Yin,
Guan Zhu

Published: March 27, 2023
https://doi.org/10.1371/journal.pntd.0011217

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