A drug repurposing screen for whipworms informed by comparative genomics

Avril Coghlan; Frederick A. Partridge; María Adelaida Duque-Correa; Gabriel Rinaldi; Simon Clare; Lisa Seymour; Cordelia Brandt; Tapoka T. Mkandawire; Catherine McCarthy; Nancy Holroyd; Marina Nick; Anwen E. Brown; Sirapat Tonitiwong; David B. Sattelle; Matthew Berriman

doi:10.1371/journal.pntd.0011205

Loading metrics

Open Access

Peer-reviewed

Research Article

A drug repurposing screen for whipworms informed by comparative genomics

Avril Coghlan ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

¶‡ AC, FAP, MAD-C and GR share first authorship on this work. DBS and MB are joint senior authors on this work.

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom

https://orcid.org/0000-0002-2775-5951

⨯
Frederick A. Partridge ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – review & editing

Current address: School of Life Sciences, University of Westminster, London, United Kingdom

¶‡ AC, FAP, MAD-C and GR share first authorship on this work. DBS and MB are joint senior authors on this work.

Affiliations University College London, London, United Kingdom, School of Life Sciences, University of Westminster, London, United Kingdom
⨯
María Adelaida Duque-Correa ,

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Current address: Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom

¶‡ AC, FAP, MAD-C and GR share first authorship on this work. DBS and MB are joint senior authors on this work.

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom
⨯
Gabriel Rinaldi ,

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Current address: Department of Life Sciences, Aberystwyth University, Aberystwyth, United Kingdom

¶‡ AC, FAP, MAD-C and GR share first authorship on this work. DBS and MB are joint senior authors on this work.

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom
⨯
Simon Clare,

Roles Investigation, Methodology, Supervision

Current address: Department of Medicine, University of Cambridge, Cambridge, United Kingdom

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom
⨯
Lisa Seymour,

Roles Investigation, Methodology

Current address: Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom
⨯
Cordelia Brandt,

Roles Investigation, Methodology

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom
⨯
Tapoka T. Mkandawire,

Roles Investigation

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom
⨯
Catherine McCarthy,

Roles Investigation

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom
⨯
Nancy Holroyd,

Roles Project administration, Writing – review & editing

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom
⨯
Marina Nick,

Roles Investigation

Affiliation University College London, London, United Kingdom
⨯
Anwen E. Brown,

Roles Investigation

Affiliation University College London, London, United Kingdom
⨯
Sirapat Tonitiwong,

Roles Formal analysis, Investigation

Affiliation University College London, London, United Kingdom
⨯
David B. Sattelle ,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

¶‡ AC, FAP, MAD-C and GR share first authorship on this work. DBS and MB are joint senior authors on this work.

Affiliation University College London, London, United Kingdom
⨯
Matthew Berriman

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: Matt.Berriman@glasgow.ac.uk

Current address: School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom

¶‡ AC, FAP, MAD-C and GR share first authorship on this work. DBS and MB are joint senior authors on this work.

Affiliation Wellcome Sanger Institute, Cambridge, United Kingdom

https://orcid.org/0000-0002-9581-0377

⨯

A drug repurposing screen for whipworms informed by comparative genomics

Avril Coghlan,
Frederick A. Partridge,
María Adelaida Duque-Correa,
Gabriel Rinaldi,
Simon Clare,
Lisa Seymour,
Cordelia Brandt,
Tapoka T. Mkandawire,
Catherine McCarthy,
Nancy Holroyd

Published: September 5, 2023
https://doi.org/10.1371/journal.pntd.0011205

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Drug screening
Is the Subject Area "Drug screening" applicable to this article?

Thanks for your feedback.
Immune receptors
Is the Subject Area "Immune receptors" applicable to this article?

Thanks for your feedback.
Caenorhabditis elegans
Is the Subject Area "Caenorhabditis elegans" applicable to this article?

Thanks for your feedback.
Trichuriasis
Is the Subject Area "Trichuriasis" applicable to this article?

Thanks for your feedback.
Library screening
Is the Subject Area "Library screening" applicable to this article?

Thanks for your feedback.
Gastrointestinal tract
Is the Subject Area "Gastrointestinal tract" applicable to this article?

Thanks for your feedback.
Drug therapy
Is the Subject Area "Drug therapy" applicable to this article?

Thanks for your feedback.
Trichuris
Is the Subject Area "Trichuris" applicable to this article?

Thanks for your feedback.