Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein

• John M. Powers ,

  Contributed equally to this work with: John M. Powers, Zoe L. Lyski, Whitney C. Weber

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Current address: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America

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• Zoe L. Lyski ,

  Contributed equally to this work with: John M. Powers, Zoe L. Lyski, Whitney C. Weber

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Current address: Department of Immunobiology, University of Arizona, Tucson, Arizona, United States of America

  Affiliation Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America

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• Whitney C. Weber ,

  Contributed equally to this work with: John M. Powers, Zoe L. Lyski, Whitney C. Weber

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America

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• Michael Denton,

  Roles Investigation, Methodology

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America

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• Magdalene M. Streblow,

  Roles Investigation

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America

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• Adam T. Mayo,

  Roles Investigation

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America

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• Nicole N. Haese,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America

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• Chad D. Nix,

  Roles Investigation, Methodology

  Affiliation Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America

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• Rachel Rodríguez-Santiago,

  Roles Resources, Writing – review & editing

  Affiliation Ponce Health Sciences University/ Ponce Research Institute, Ponce, Puerto Rico

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• Luisa I. Alvarado,

  Roles Resources, Writing – review & editing

  Affiliation Ponce Health Sciences University/ Ponce Research Institute, Ponce, Puerto Rico

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• Vanessa Rivera-Amill,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Ponce Health Sciences University/ Ponce Research Institute, Ponce, Puerto Rico

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• William B. Messer ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: messer@ohsu.edu (WBM); streblow@ohsu.edu (DNS)

  Affiliations Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Medicine, Division of Infectious Disease Oregon Health and Science University, Portland, Oregon, United States of America, OHSU-PSU School of Public Health, Program in Epidemiology, Oregon Health and Science University, Portland, Oregon, United States of America

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• Daniel N. Streblow

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: messer@ohsu.edu (WBM); streblow@ohsu.edu (DNS)

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0002-6828-2492

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