Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation

Jaime Altcheh; Guillermo Moscatelli; Martin Caruso; Samanta Moroni; Margarita Bisio; Maria Rosa Miranda; Celia Monla; Maria Vaina; Maria Valdez; Lucrecia Moran; Teresa Ramirez; Oscar Ledesma Patiño; Adelina Riarte; Nicolas Gonzalez; Jayme Fernandes; Fabiana Alves; Isabela Ribeiro; Facundo Garcia-Bournissen

doi:10.1371/journal.pntd.0010850

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Open Access

Peer-reviewed

Research Article

Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation

Jaime Altcheh,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Servicio de Parasitologia y Chagas, Hospital de Niños “Dr Ricardo Gutierrez”, Buenos Aires, Argentina, PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Instituto de Investigaciones en Patologias Pediatricas (IMIPP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
⨯
Guillermo Moscatelli,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations Servicio de Parasitologia y Chagas, Hospital de Niños “Dr Ricardo Gutierrez”, Buenos Aires, Argentina, PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Instituto de Investigaciones en Patologias Pediatricas (IMIPP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
⨯
Martin Caruso,

Roles Investigation, Writing – review & editing

Affiliations PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Hospital de Niños Doctor Hector Quintana, Jujuy, Argentina
⨯
Samanta Moroni,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations Servicio de Parasitologia y Chagas, Hospital de Niños “Dr Ricardo Gutierrez”, Buenos Aires, Argentina, PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Instituto de Investigaciones en Patologias Pediatricas (IMIPP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
⨯
Margarita Bisio,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations Servicio de Parasitologia y Chagas, Hospital de Niños “Dr Ricardo Gutierrez”, Buenos Aires, Argentina, PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Instituto de Investigaciones en Patologias Pediatricas (IMIPP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
⨯
Maria Rosa Miranda,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Hospital de Niños Doctor Hector Quintana, Jujuy, Argentina
⨯
Celia Monla,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Hospital Público Materno Infantil, Salta, Argentina
⨯
Maria Vaina,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Hospital Público Materno Infantil, Salta, Argentina
⨯
Maria Valdez,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Hospital Público Materno Infantil, Salta, Argentina
⨯
Lucrecia Moran,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Centro de Chagas y Patología Regional, Santiago del Estero, Argentina
⨯
Teresa Ramirez,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina
⨯
Oscar Ledesma Patiño,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Centro de Chagas y Patología Regional, Santiago del Estero, Argentina
⨯
Adelina Riarte,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Instituto Nacional de Parasitología Dr. Mario Fatala Chaben, Buenos Aires, Argentina
⨯
Nicolas Gonzalez,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations Servicio de Parasitologia y Chagas, Hospital de Niños “Dr Ricardo Gutierrez”, Buenos Aires, Argentina, PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Instituto de Investigaciones en Patologias Pediatricas (IMIPP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
⨯
Jayme Fernandes,

Roles Project administration, Writing – review & editing

Affiliation Drugs for Neglected Diseases initiative, Rio de Janeiro, Brazil
⨯
Fabiana Alves,

Roles Conceptualization, Methodology, Project administration, Writing – review & editing

Affiliation Drugs for Neglected Diseases initiative, Geneva, Switzerland
⨯
Isabela Ribeiro,

Roles Conceptualization, Formal analysis, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Drugs for Neglected Diseases initiative, Geneva, Switzerland

https://orcid.org/0000-0001-7402-4628

⨯
[ ... ],
Facundo Garcia-Bournissen

Roles Conceptualization, Formal analysis, Methodology, Resources, Supervision, Writing – review & editing

* E-mail: fgarciab@uwo.ca

Affiliations Servicio de Parasitologia y Chagas, Hospital de Niños “Dr Ricardo Gutierrez”, Buenos Aires, Argentina, PEDCHAGAS Network (Hospital de Niños Ricardo Gutiérrez, Hospital de Niños Doctor Hector Quintana, Hospital Público Materno Infantil, Centro de Chagas y Patología Regional de Santiago del Estero, & Instituto Nacional de Parasitología Dr. Mario Fatala Chaben), Argentina, Division of Paediatric Clinical Pharmacology, Department of Paediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada
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Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation

Jaime Altcheh,
Guillermo Moscatelli,
Martin Caruso,
Samanta Moroni,
Margarita Bisio,
Maria Rosa Miranda,
Celia Monla,
Maria Vaina,
Maria Valdez,
Lucrecia Moran

Published: May 31, 2023
https://doi.org/10.1371/journal.pntd.0010850

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