Human Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease

• Pablo M. De Salazar ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: pablom@hsph.harvard.edu

  Affiliation Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-8096-2001

  ⨯
• Sergio Sosa-Estani,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

  Affiliations Drugs for Neglected Diseases Initiative. Rio de Janeiro, Brazil, Epidemiology and Public Health Research Centre, CONICET, Buenos Aires, Argentina

  ⨯
• Fernando Salvador,

  Roles Data curation, Investigation, Resources, Writing – review & editing

  Affiliations Department of Infectious Diseases, Vall d’Hebron University Hospital, International Health Program of the Catalan Institute of Health (PROSICS), Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

  ⨯
• Elena Sulleiro,

  Roles Data curation, Investigation

  Affiliations Department of Microbiology, Vall d’Hebron University Hospital, International Health Program of the Catalan Institute of Health (PROSICS), Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

  ⨯
• Adrián Sánchez-Montalvá,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Infectious Diseases, Vall d’Hebron University Hospital, International Health Program of the Catalan Institute of Health (PROSICS), Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

  ⨯
• Isabela Ribeiro,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Drugs for Neglected Diseases Initiative, Geneve, Switzerland

  ⨯
• Israel Molina ,

  Contributed equally to this work with: Israel Molina, Caroline O. Buckee

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Infectious Diseases, Vall d’Hebron University Hospital, International Health Program of the Catalan Institute of Health (PROSICS), Barcelona, Spain, Instituto René Rachou-FIOCRUZ Minas, Laboratório de Triatomíneos e Epidemiologia da Doença de Chagas, Belo Horizonte, Brazil, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

  ⨯
• Caroline O. Buckee

  Contributed equally to this work with: Israel Molina, Caroline O. Buckee

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯