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Open Access
Peer-reviewed
Research Article
Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response
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Edubiel A. Alpizar-Sosa,
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliations Wellcome Centre for Integrative Parasitology, School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Department of Biosciences, Durham University, Durham, United Kingdom
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Nur Raihana Binti Ithnin,
Roles Formal analysis, Funding acquisition, Investigation, Methodology
Affiliations Wellcome Centre for Integrative Parasitology, School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Department of Medical Microbiology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
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Wenbin Wei,
Roles Formal analysis
Affiliation Department of Biosciences, Durham University, Durham, United Kingdom
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Andrew W. Pountain,
Roles Formal analysis, Methodology, Writing – review & editing
Affiliations Wellcome Centre for Integrative Parasitology, School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Institute for Computational Medicine, New York University Grossman School of Medicine, New York City, New York, United States of America
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Stefan K. Weidt,
Roles Formal analysis, Investigation, Methodology
Affiliation Glasgow Polyomics, College of Medical, Veterinary & Life Sciences, University of Glasgow, Garscube Estate, Bearsden, Glasgow, United Kingdom
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Anne M. Donachie,
Roles Investigation, Methodology
Affiliation Wellcome Centre for Integrative Parasitology, School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Ryan Ritchie,
Roles Investigation, Methodology
Affiliation Wellcome Centre for Integrative Parasitology, School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Emily A. Dickie,
Roles Writing – review & editing
Affiliations Wellcome Centre for Integrative Parasitology, School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Glasgow Polyomics, College of Medical, Veterinary & Life Sciences, University of Glasgow, Garscube Estate, Bearsden, Glasgow, United Kingdom
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Richard J. S. Burchmore,
Roles Supervision
Affiliations Wellcome Centre for Integrative Parasitology, School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Glasgow Polyomics, College of Medical, Veterinary & Life Sciences, University of Glasgow, Garscube Estate, Bearsden, Glasgow, United Kingdom
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Paul W. Denny,
Roles Funding acquisition, Writing – review & editing
Affiliation Department of Biosciences, Durham University, Durham, United Kingdom
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Michael P. Barrett
Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: michael.barrett@glasgow.ac.uk
Affiliations Wellcome Centre for Integrative Parasitology, School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Glasgow Polyomics, College of Medical, Veterinary & Life Sciences, University of Glasgow, Garscube Estate, Bearsden, Glasgow, United Kingdom
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Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response
- Edubiel A. Alpizar-Sosa,
- Nur Raihana Binti Ithnin,
- Wenbin Wei,
- Andrew W. Pountain,
- Stefan K. Weidt,
- Anne M. Donachie,
- Ryan Ritchie,
- Emily A. Dickie,
- Richard J. S. Burchmore,
- Paul W. Denny
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- Published: September 28, 2022
- https://doi.org/10.1371/journal.pntd.0010779