A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus macaque (Macaca mulatta) model

• Manutsanun Inthawong,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Veterinary Medicine, United States Army Medical Directorate, Armed Forces Research Institute of Medical Sciences (USAMD-AFRIMS), Bangkok, Thailand, Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

  https://orcid.org/0000-0002-8956-4253

  ⨯
• Piyanate Sunyakumthorn,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Veterinary Medicine, United States Army Medical Directorate, Armed Forces Research Institute of Medical Sciences (USAMD-AFRIMS), Bangkok, Thailand

  ⨯
• Sirima Wongwairot,

  Roles Data curation, Investigation, Methodology

  Affiliations Department of Veterinary Medicine, United States Army Medical Directorate, Armed Forces Research Institute of Medical Sciences (USAMD-AFRIMS), Bangkok, Thailand, Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

  ⨯
• Tippawan Anantatat,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America

  ⨯
• Susanna J. Dunachie,

  Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom

  ⨯
• Rawiwan Im-Erbsin,

  Roles Investigation, Methodology, Supervision

  Affiliation Department of Veterinary Medicine, United States Army Medical Directorate, Armed Forces Research Institute of Medical Sciences (USAMD-AFRIMS), Bangkok, Thailand

  ⨯
• James W. Jones,

  Roles Conceptualization, Funding acquisition, Project administration, Resources

  Affiliation Department of Veterinary Medicine, United States Army Medical Directorate, Armed Forces Research Institute of Medical Sciences (USAMD-AFRIMS), Bangkok, Thailand

  ⨯
• Carl J. Mason,

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources

  Affiliation Department of Veterinary Medicine, United States Army Medical Directorate, Armed Forces Research Institute of Medical Sciences (USAMD-AFRIMS), Bangkok, Thailand

  ⨯
• Luis A. Lugo,

  Roles Conceptualization, Methodology, Supervision

  Affiliation Department of Veterinary Medicine, United States Army Medical Directorate, Armed Forces Research Institute of Medical Sciences (USAMD-AFRIMS), Bangkok, Thailand

  ⨯
• Stuart D. Blacksell,

  Roles Formal analysis, Investigation, Methodology, Supervision, Validation

  Affiliations Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom

  ⨯
• Nicholas P. J. Day,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  Affiliations Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom

  ⨯
• Piengchan Sonthayanon,

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

  ⨯
• Allen L. Richards,

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Viral & Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, United States of America, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

  ⨯
• Daniel H. Paris

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: daniel.paris@swisstph.ch

  Affiliations Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom, Department of Medicine, Swiss Tropical and Public Health Institute, Faculty of Medicine, University of Basel, Switzerland, Department of Clinical Research, Faculty of Medicine, University of Basel, Switzerland

  https://orcid.org/0000-0003-4743-5987

  ⨯