Zika virus-like particle vaccine fusion loop mutation increases production yield but fails to protect AG129 mice against Zika virus challenge

• Danielle Thompson,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Emergent BioSolutions Inc., Gaithersburg, Maryland, United States of America

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• Ben Guenther,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Emergent BioSolutions Inc., Gaithersburg, Maryland, United States of America

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• Darly Manayani,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Current address: Novartis Gene Therapies, San Diego California, United States of America

  Affiliation PaxVax Inc., San Diego, California, United States of America

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• Jason Mendy,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Emergent BioSolutions Inc., Gaithersburg, Maryland, United States of America

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• Jonathan Smith,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  Current address: VLP Therapeutics, Inc., Gaithersburg, Maryland, United States of America

  Affiliation PaxVax Inc., San Diego, California, United States of America

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• Diego A. Espinosa,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Current address: Metagenomi, Emeryville, California, United States of America

  Affiliation Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, United States of America

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• Eva Harris,

  Roles Conceptualization, Writing – review & editing

  Affiliation Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, United States of America

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• Jeff Alexander,

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Emergent BioSolutions Inc., Gaithersburg, Maryland, United States of America, PaxVax Inc., San Diego, California, United States of America

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• Lo Vang,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Emergent BioSolutions Inc., Gaithersburg, Maryland, United States of America

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• Christopher S. Morello

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: MorelloC@ebsi.com

  Affiliation Emergent BioSolutions Inc., Gaithersburg, Maryland, United States of America

  https://orcid.org/0000-0001-8113-1173

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