Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation

Yegnasew Takele; Emebet Adem; Susanne Ursula Franssen; Rebecca Womersley; Myrsini Kaforou; Michael Levin; Ingrid Müller; James Anthony Cotton; Pascale Kropf

doi:10.1371/journal.pntd.0010544

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Open Access

Peer-reviewed

Research Article

Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation

Yegnasew Takele,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

Affiliations Department of Infectious Disease, Imperial College London, London, United Kingdom, Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom
⨯
Emebet Adem,

Roles Formal analysis, Investigation, Writing – review & editing

Current address: University of Greenwich at Medway, Kent, United Kingdom

Affiliation Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia
⨯
Susanne Ursula Franssen,

Roles Formal analysis, Writing – review & editing

Current address: Division of Evolutionary Biology, Faculty of Biology, LMU Munich, Germany

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom
⨯
Rebecca Womersley,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Infectious Disease, Imperial College London, London, United Kingdom
⨯
Myrsini Kaforou,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Infectious Disease, Imperial College London, London, United Kingdom
⨯
Michael Levin,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Infectious Disease, Imperial College London, London, United Kingdom
⨯
Ingrid Müller,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Disease, Imperial College London, London, United Kingdom
⨯
James Anthony Cotton,

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom
⨯
Pascale Kropf

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

* E-mail: p.kropf@imperial.ac.uk

Affiliation Department of Infectious Disease, Imperial College London, London, United Kingdom

https://orcid.org/0000-0002-1670-8332

⨯

Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation

Yegnasew Takele,
Emebet Adem,
Susanne Ursula Franssen,
Rebecca Womersley,
Myrsini Kaforou,
Michael Levin,
Ingrid Müller,
James Anthony Cotton,
Pascale Kropf

Published: June 24, 2022
https://doi.org/10.1371/journal.pntd.0010544

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