COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-κB signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis

• Yudan Zhao ,

  Contributed equally to this work with: Yudan Zhao, Yongwu Yang

  Roles Data curation, Formal analysis, Investigation, Writing – original draft

  Affiliation Heilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Yongwu Yang ,

  Contributed equally to this work with: Yudan Zhao, Yongwu Yang

  Roles Formal analysis, Investigation, Methodology, Resources

  Affiliation Heilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Min Liu,

  Roles Formal analysis, Investigation

  Affiliation Heilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Xuening Qin,

  Roles Formal analysis, Investigation

  Affiliation Heilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Xiran Yu,

  Roles Methodology

  Affiliation Heilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Huimin Zhao,

  Roles Investigation

  Affiliation Heilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Xiaoyun Li,

  Roles Resources

  Affiliation Heilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Wei Li

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: neaulw@gmail.com

  Affiliation Heilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  https://orcid.org/0000-0002-4264-1864

  ⨯