Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion

• Zhe-Rui Zhang ,

  Contributed equally to this work with: Zhe-Rui Zhang, Ya-Nan Zhang, Hong-Qing Zhang

  Roles Data curation, Investigation, Writing – original draft

  Affiliations Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China

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• Ya-Nan Zhang ,

  Contributed equally to this work with: Zhe-Rui Zhang, Ya-Nan Zhang, Hong-Qing Zhang

  Roles Data curation, Investigation, Writing – original draft

  Affiliations Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China

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• Hong-Qing Zhang ,

  Contributed equally to this work with: Zhe-Rui Zhang, Ya-Nan Zhang, Hong-Qing Zhang

  Roles Data curation, Investigation, Writing – original draft

  Affiliations Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China

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• Qiu-Yan Zhang,

  Roles Investigation

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

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• Na Li,

  Roles Investigation

  Affiliations Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China

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• Qi Li,

  Roles Investigation

  Affiliation Drug Discovery Center for Infectious Disease, Nankai University, Tianjin, People’s Republic of China

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• Cheng-Lin Deng,

  Roles Investigation, Methodology

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

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• Bo Zhang,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliations Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China, Drug Discovery Center for Infectious Disease, Nankai University, Tianjin, People’s Republic of China

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• Xiao-Dan Li ,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  * E-mail: lxd@live.cn (XDL); yehq@wh.iov.cn (HQY)

  Affiliation Hunan Normal University, School of Medicine, Changsha, China

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• Han-Qing Ye

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  * E-mail: lxd@live.cn (XDL); yehq@wh.iov.cn (HQY)

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

  https://orcid.org/0000-0001-7770-4071

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