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Open Access
Peer-reviewed
Research Article
Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities
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Tushabe John Vianney,
Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing
Affiliations Parasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom, Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute and the London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda
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Duncan J. Berger,
Roles Formal analysis, Investigation, Writing – review & editing
Affiliation Parasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom
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Stephen R. Doyle,
Roles Formal analysis, Investigation, Writing – review & editing
Affiliation Parasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom
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Geetha Sankaranarayanan,
Roles Investigation, Resources, Writing – review & editing
Affiliation Parasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom
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Joel Serubanja,
Roles Investigation, Resources, Writing – review & editing
Affiliation Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute and the London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda
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Prossy Kabuubi Nakawungu,
Roles Investigation, Writing – review & editing
Affiliation Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute and the London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda
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Fred Besigye,
Roles Investigation, Writing – review & editing
Affiliation Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute and the London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda
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Richard E. Sanya,
Roles Conceptualization, Investigation, Resources, Writing – review & editing
Affiliations Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute and the London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda, Health and Systems for Health Unit, African Population and Health Research Center, Nairobi, Kenya
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Nancy Holroyd,
Roles Project administration, Writing – review & editing
Affiliation Parasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom
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Fiona Allan,
Roles Investigation, Methodology, Resources, Writing – review & editing
Affiliation Department of Life Sciences, Natural History Museum, London, United Kingdom
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Emily L. Webb,
Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing
Affiliation MRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Alison M. Elliott ,
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: Alison.Elliott@lshtm.ac.uk (AME); matt.berriman@glasgow.ac.uk (MB); james.cotton@glasgow.ac.uk (JAC)
Affiliations Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute and the London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda, Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Matthew Berriman ,
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: Alison.Elliott@lshtm.ac.uk (AME); matt.berriman@glasgow.ac.uk (MB); james.cotton@glasgow.ac.uk (JAC)
Current address: Wellcome Center for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom
Affiliation Parasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom
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James A. Cotton
Roles Formal analysis, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Alison.Elliott@lshtm.ac.uk (AME); matt.berriman@glasgow.ac.uk (MB); james.cotton@glasgow.ac.uk (JAC)
Current address: Wellcome Center for Integrative Parasitology, School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom
Affiliation Parasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom
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Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities
- Tushabe John Vianney,
- Duncan J. Berger,
- Stephen R. Doyle,
- Geetha Sankaranarayanan,
- Joel Serubanja,
- Prossy Kabuubi Nakawungu,
- Fred Besigye,
- Richard E. Sanya,
- Nancy Holroyd,
- Fiona Allan
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- Published: August 18, 2022
- https://doi.org/10.1371/journal.pntd.0010188