Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort

• Manuela da Silva Solcà ,

  Contributed equally to this work with: Manuela da Silva Solcà, Maiara Reis Arruda

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil, Escola de Medicina Veterinária e Zootecnia—Universidade Federal da Bahia, Bahia, Brazil

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• Maiara Reis Arruda ,

  Contributed equally to this work with: Manuela da Silva Solcà, Maiara Reis Arruda

  Roles Data curation, Investigation, Methodology

  Affiliation Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil

  https://orcid.org/0000-0001-9116-135X

  ⨯
• Bruna Martins Macedo Leite,

  Roles Investigation, Methodology

  Affiliation Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil

  https://orcid.org/0000-0002-0763-1361

  ⨯
• Tiago Feitosa Mota,

  Roles Investigation, Methodology

  Affiliation Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil

  https://orcid.org/0000-0001-6575-8208

  ⨯
• Miriam Flores Rebouças,

  Roles Investigation, Methodology

  Affiliation Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil

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• Matheus Silva de Jesus,

  Roles Investigation, Methodology

  Affiliation Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil

  https://orcid.org/0000-0003-0166-9948

  ⨯
• Leila Denise Alves Ferreira Amorim,

  Roles Formal analysis

  Affiliation Instituto de Matemática e Estatística—Universidade Federal da Bahia, Bahia, Brazil

  https://orcid.org/0000-0002-1112-2332

  ⨯
• Valéria Matos Borges,

  Roles Conceptualization

  Affiliation Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil

  https://orcid.org/0000-0002-2775-5409

  ⨯
• Jesus Valenzuela,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliation Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

  https://orcid.org/0000-0002-5589-9450

  ⨯
• Shaden Kamhawi,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliation Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

  https://orcid.org/0000-0003-4304-636X

  ⨯
• Patrícia Sampaio Tavares Veras,

  Roles Conceptualization

  Affiliations Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil, Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais / INCT-DT, Bahia, Brazil

  ⨯
• Deborah Bittencourt Mothé Fraga ,

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶‡ DBMF and CIB also contributed equally to this work.

  Affiliations Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil, Escola de Medicina Veterinária e Zootecnia—Universidade Federal da Bahia, Bahia, Brazil, Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais / INCT-DT, Bahia, Brazil

  https://orcid.org/0000-0003-4788-0319

  ⨯
• Claudia Ida Brodskyn

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: claudia.brodskyn@fiocruz.br, cbrodskyn2009@gmail.com

  ¶‡ DBMF and CIB also contributed equally to this work.

  Affiliations Instituto Gonçalo Moniz—Fundação Oswaldo Cruz, Bahia, Brazil, Instituto Nacional de Ciência e Tecnologia-Investigação em Imunologia /INCT-III, São Paulo, Brazil

  https://orcid.org/0000-0003-3367-5365

  ⨯