Immortalized stem cell-derived hepatocyte-like cells: An alternative model for studying dengue pathogenesis and therapy

• Kessiri Kongmanas ,

  Contributed equally to this work with: Kessiri Kongmanas, Nuntaya Punyadee

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft

  Affiliations Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Siriraj Metabolomics and Phenomics Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

  https://orcid.org/0000-0002-5937-7254

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• Nuntaya Punyadee ,

  Contributed equally to this work with: Kessiri Kongmanas, Nuntaya Punyadee

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization

  Affiliations Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

  ⨯
• Kasima Wasuworawong,

  Roles Investigation, Methodology, Visualization

  Affiliation Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

  https://orcid.org/0000-0003-2602-277X

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• Adisak Songjaeng,

  Roles Investigation, Methodology

  Affiliation Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

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• Tanapan Prommool,

  Roles Investigation, Methodology

  Affiliation Molecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok, Thailand

  ⨯
• Yongyut Pewkliang,

  Roles Investigation, Methodology, Visualization

  Affiliation Excellent Center for Drug Discovery, Faculty of Science, Mahidol University, Bangkok, Thailand

  https://orcid.org/0000-0003-2267-7883

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• Siriphan Manocheewa,

  Roles Investigation, Methodology

  Affiliation Siriraj Metabolomics and Phenomics Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

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• Somchai Thiemmeca,

  Roles Investigation, Methodology

  Affiliations Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Graduate Program in Immunology, Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

  https://orcid.org/0000-0002-6720-1435

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• Khanit Sa-ngiamsuntorn,

  Roles Investigation, Methodology

  Affiliation Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand

  https://orcid.org/0000-0001-7010-345X

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• Chunya Puttikhunt,

  Roles Methodology

  Affiliations Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Molecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok, Thailand

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• Kym Francis Faull,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, California, United States of America

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• Suradej Hongeng,

  Roles Funding acquisition, Methodology, Supervision

  Affiliation Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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• Panisadee Avirutnan

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: panisadee.avi@mahidol.edu

  Affiliations Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Siriraj Metabolomics and Phenomics Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Molecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok, Thailand

  https://orcid.org/0000-0003-0053-3045

  ⨯