Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers

• Federica Fratini ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

  * E-mail: federica.fratini@iss.it

  Affiliations Proteomics Core Facility, Istituto Superiore di Sanità(ISS), Rome, Italy, Who Collaborating Centre for Epidemiology, Detection and Control of Cystic and Alveolar Echinococcosis, Department of Infectious, Diseases (DMI), ISS, Rome, Italy

  http://orcid.org/0000-0003-0807-930X

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• F. Tamarozzi,

  Roles Conceptualization, Data curation, Investigation, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Who Collaborating Centre for Epidemiology, Detection and Control of Cystic and Alveolar Echinococcosis, Department of Infectious, Diseases (DMI), ISS, Rome, Italy

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• G. Macchia,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Proteomics Core Facility, Istituto Superiore di Sanità(ISS), Rome, Italy

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• L. Bertuccini,

  Roles Formal analysis, Writing – review & editing

  Affiliation Electron Microscopy Core Facility, ISS, Rome, Italy

  http://orcid.org/0000-0002-4278-2376

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• M. Mariconti,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy

  http://orcid.org/0000-0003-4154-930X

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• C. Birago,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Infectious, Diseases (DMI), ISS, Rome, Italy

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• A. Iriarte,

  Roles Formal analysis, Writing – review & editing

  Affiliation Laboratorio de Biología Computacional, Dpto. de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

  http://orcid.org/0000-0002-5862-0152

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• E. Brunetti,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy

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• CM. Cretu,

  Roles Investigation, Writing – review & editing

  Affiliation University of Medicine and Pharmacy, Colentina Clinical Hospital—Parasitology, Bucharest, Romania

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• O. Akhan,

  Roles Investigation, Writing – review & editing

  Affiliation Faculty of Medicine, Hacettepe University, Ankara, Turkey

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• M. Siles-Lucas,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Instituto de Recursos Naturales y Agrobiologı´a de Salamanca (IRNASA-CSIC), Salamanca, Spain

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• A. Díaz,

  Roles Data curation, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Área Inmunología, Departamento de Biociencias, Facultad de Química, Universidad de la República, Montevideo, Uruguay

  http://orcid.org/0000-0001-5375-6766

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• Adriano Casulli

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliations Who Collaborating Centre for Epidemiology, Detection and Control of Cystic and Alveolar Echinococcosis, Department of Infectious, Diseases (DMI), ISS, Rome, Italy, European Reference Laboratory for Parasites (EURLP), DMI, ISS, Rome, Italy

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