An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans

• Meghan A. Guzman ,

  Contributed equally to this work with: Meghan A. Guzman, Anastasia R. Rugel

  Roles Investigation, Methodology, Writing – original draft

  Affiliations Departments of Biochemistry and Structural Biology, the University of Texas Health Science Center, San Antonio, Texas, United States of America, Pathology and Laboratory Medicine, the University of Texas Health Science Center, San Antonio, Texas, United States of America

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• Anastasia R. Rugel ,

  Contributed equally to this work with: Meghan A. Guzman, Anastasia R. Rugel

  Roles Investigation, Methodology, Writing – original draft

  Current address: APO 2900 Crystal Drive, Arlington, Virginia, United States of America

  Affiliations Departments of Biochemistry and Structural Biology, the University of Texas Health Science Center, San Antonio, Texas, United States of America, Pathology and Laboratory Medicine, the University of Texas Health Science Center, San Antonio, Texas, United States of America

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• Reid S. Tarpley,

  Roles Investigation, Methodology

  Current address: University of Notre Dame, Department of Chemistry & Biochemistry, Notre Dame, Indiana, United States of America

  Affiliation Center for Innovative Drug Discovery, Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas, United States of America

  http://orcid.org/0000-0003-2431-0831

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• Sevan N. Alwan,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Departments of Biochemistry and Structural Biology, the University of Texas Health Science Center, San Antonio, Texas, United States of America

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• Frédéric D. Chevalier,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Program in Host-Pathogen Interactions, Texas Biomedical Research Institute, San Antonio, Texas, United States of America

  http://orcid.org/0000-0003-2611-8106

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• Dmytro P. Kovalskyy,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Departments of Biochemistry and Structural Biology, the University of Texas Health Science Center, San Antonio, Texas, United States of America

  http://orcid.org/0000-0002-1143-8724

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• Xiaohang Cao,

  Roles Investigation, Methodology

  Affiliation Departments of Biochemistry and Structural Biology, the University of Texas Health Science Center, San Antonio, Texas, United States of America

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• Stephen P. Holloway,

  Roles Methodology

  Affiliation Departments of Biochemistry and Structural Biology, the University of Texas Health Science Center, San Antonio, Texas, United States of America

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• Timothy J. C. Anderson,

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Program in Disease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, Texas, United States of America

  http://orcid.org/0000-0002-0191-0204

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• Alexander B. Taylor,

  Roles Conceptualization, Data curation, Resources, Supervision, Writing – review & editing

  Affiliations Departments of Biochemistry and Structural Biology, the University of Texas Health Science Center, San Antonio, Texas, United States of America, X-ray Crystallography Core Laboratory, Institutional Research Cores, University of Texas Health Science Center, San Antonio, Texas, United States of America

  http://orcid.org/0000-0003-3517-6033

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• Stanton F. McHardy ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: tanton.McHardy@utsa.edu (SFM); loverde@uthscsa.edu (PTL)

  ¶‡ SFM and PTL also contributed equally to this work.

  Affiliation Center for Innovative Drug Discovery, Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas, United States of America

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• Philip T. LoVerde

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: tanton.McHardy@utsa.edu (SFM); loverde@uthscsa.edu (PTL)

  ¶‡ SFM and PTL also contributed equally to this work.

  Affiliations Departments of Biochemistry and Structural Biology, the University of Texas Health Science Center, San Antonio, Texas, United States of America, Pathology and Laboratory Medicine, the University of Texas Health Science Center, San Antonio, Texas, United States of America

  http://orcid.org/0000-0002-8316-8559

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