Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme

• Lorenzo Turcano ,

  Contributed equally to this work with: Lorenzo Turcano, Theo Battista

  Roles Data curation, Investigation, Visualization

  Affiliation Department of Translational and Discovery Research, Pomezia (Roma) Italy

  ⨯
• Theo Battista ,

  Contributed equally to this work with: Lorenzo Turcano, Theo Battista

  Roles Investigation, Visualization

  Affiliation Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Roma, Italy

  ⨯
• Esther Torrente De Haro,

  Roles Data curation, Investigation

  Affiliation Department of Drug Discovery, Pomezia (Roma) Italy

  ⨯
• Antonino Missineo,

  Roles Investigation, Visualization

  Affiliation Department of Translational and Discovery Research, Pomezia (Roma) Italy

  ⨯
• Cristina Alli,

  Roles Investigation, Visualization

  Affiliation Department of Translational and Discovery Research, Pomezia (Roma) Italy

  ⨯
• Giacomo Paonessa,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Translational and Discovery Research, Pomezia (Roma) Italy

  ⨯
• Gianni Colotti,

  Roles Conceptualization, Supervision, Visualization, Writing – review & editing

  Affiliation Istituto di Biologia e Patologia Molecolari del CNR c/o Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Roma, Italy

  ⨯
• Steven Harper †,

  † Deceased.

  Roles Data curation, Supervision, Writing – review & editing

  Affiliation Department of Drug Discovery, Pomezia (Roma) Italy

  ⨯
• Annarita Fiorillo,

  Roles Data curation, Investigation, Visualization

  Affiliation Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Roma, Italy

  http://orcid.org/0000-0002-8966-8554

  ⨯
• Andrea Ilari ,

  Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

  * E-mail: andrea.ilari@cnr.it (AI); a.bresciani@irbm.com (AB)

  Affiliation Istituto di Biologia e Patologia Molecolari del CNR c/o Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Roma, Italy

  http://orcid.org/0000-0002-7754-399X

  ⨯
• Alberto Bresciani

  Roles Conceptualization, Data curation, Funding acquisition, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: andrea.ilari@cnr.it (AI); a.bresciani@irbm.com (AB)

  Affiliation Department of Translational and Discovery Research, Pomezia (Roma) Italy

  http://orcid.org/0000-0003-4491-603X

  ⨯