Comprehensive characterization of plasma cell-free Echinococcus spp. DNA in echinococcosis patients using ultra-high-throughput sequencing

Jingkai Ji; Bin Li; Jingzhong Li; Wangmu Danzeng; Jiandong Li; Yanping Zhao; Gezhen Qiangba; Qingda Zhang; Nibu Renzhen; Zhuoga Basang; Changlin Jia; Quzhen Gongsang; Jinmin Ma; Yicong Wang; Fang Chen; Hongcheng Zhou; Huasang; Jiefang Yin; Jiandan Xie; Na Pei; Huimin Cai; Huayan Jiang; Huanming Yang; Jian Wang; Asan; Xiumin Han; Junhua Li; Weijun Chen; Dong Yang

doi:10.1371/journal.pntd.0008148

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Open Access

Peer-reviewed

Research Article

Comprehensive characterization of plasma cell-free Echinococcus spp. DNA in echinococcosis patients using ultra-high-throughput sequencing

Jingkai Ji ,

Contributed equally to this work with: Jingkai Ji, Bin Li, Jingzhong Li

Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliations BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China, BGI-Shenzhen, Shenzhen, China, Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, China

http://orcid.org/0000-0002-9264-7746

⨯
Bin Li ,

Contributed equally to this work with: Jingkai Ji, Bin Li, Jingzhong Li

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliations Second People's Hospital of Tibet Autonomous Region, Lhasa, China, Tibet Center for Disease Control and Prevention, Lhasa, China
⨯
Jingzhong Li ,

Contributed equally to this work with: Jingkai Ji, Bin Li, Jingzhong Li

Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

Affiliations Tibet Center for Disease Control and Prevention, Lhasa, China, NHC Key Laboratory of Echinococcosis Prevention and Control (Xizang Center for Disease Control and Prevention), Lhasa, China
⨯
Wangmu Danzeng,

Roles Data curation, Resources

Affiliations BGI-Shenzhen, Shenzhen, China, BGI-Tibet, Lhasa, China
⨯
Jiandong Li,

Roles Methodology, Software, Validation, Visualization

Affiliations BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China, BGI-Shenzhen, Shenzhen, China, Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, China
⨯
Yanping Zhao,

Roles Data curation, Writing – review & editing

Affiliations BGI-Shenzhen, Shenzhen, China, Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, China
⨯
Gezhen Qiangba,

Roles Methodology, Validation, Visualization

Affiliations BGI-Shenzhen, Shenzhen, China, Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, China
⨯
Qingda Zhang,

Roles Investigation, Supervision

Affiliation Second People's Hospital of Tibet Autonomous Region, Lhasa, China
⨯
Nibu Renzhen,

Roles Investigation, Resources

Affiliation Second People's Hospital of Tibet Autonomous Region, Lhasa, China
⨯
Zhuoga Basang,

Roles Investigation, Resources

Affiliation Second People's Hospital of Tibet Autonomous Region, Lhasa, China
⨯
Changlin Jia,

Roles Investigation, Resources

Affiliation Second People's Hospital of Tibet Autonomous Region, Lhasa, China
⨯
Quzhen Gongsang,

Roles Investigation, Resources

Affiliations Second People's Hospital of Tibet Autonomous Region, Lhasa, China, NHC Key Laboratory of Echinococcosis Prevention and Control (Xizang Center for Disease Control and Prevention), Lhasa, China
⨯
Jinmin Ma,

Roles Conceptualization, Investigation

Affiliation BGI-Shenzhen, Shenzhen, China
⨯
Yicong Wang,

Roles Data curation, Investigation

Affiliation MGI, BGI-Shenzhen, Shenzhen, China
⨯
Fang Chen,

Roles Data curation, Investigation

Affiliations MGI, BGI-Shenzhen, Shenzhen, China, MGI-Wuhan, BGI-Shenzhen, Wuhan, China
⨯
Hongcheng Zhou,

Roles Resources

Affiliation BGI-Shenzhen, Shenzhen, China
⨯
Huasang,

Roles Investigation, Resources

Affiliations BGI-Shenzhen, Shenzhen, China, BGI-Tibet, Lhasa, China
⨯
Jiefang Yin,

Roles Project administration, Supervision

Affiliations BGI-Shenzhen, Shenzhen, China, Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, China
⨯
Jiandan Xie,

Roles Formal analysis, Software

Affiliations BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China, BGI-Shenzhen, Shenzhen, China, Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, China
⨯
Na Pei,

Roles Methodology, Validation

Affiliations BGI-Shenzhen, Shenzhen, China, Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, China
⨯
Huimin Cai,

Roles Formal analysis, Software, Visualization

Affiliations BGI-Shenzhen, Shenzhen, China, Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, China, People's Hospital of Qinghai, Xining, China
⨯
Huayan Jiang,

Roles Project administration

Affiliation BGI-Shenzhen, Shenzhen, China
⨯
Huanming Yang,

Roles Supervision

Affiliations BGI-Shenzhen, Shenzhen, China, James D. Watson Institute of Genome Sciences, Hangzhou, China
⨯
Jian Wang,

Roles Supervision

Affiliation BGI-Shenzhen, Shenzhen, China
⨯
Asan,

Roles Conceptualization, Supervision

Affiliations BGI-Shenzhen, Shenzhen, China, BGI-Tibet, Lhasa, China
⨯
Xiumin Han,

Roles Conceptualization, Investigation

Affiliation People's Hospital of Qinghai, Xining, China
⨯
Junhua Li ,

Roles Formal analysis, Methodology, Software, Writing – review & editing

* E-mail: lijunhua@genomics.cn (JL); chenwj@bgi.com (WC); yangdong1975@sina.com (DY)

Affiliations BGI-Shenzhen, Shenzhen, China, Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, China, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China
⨯
Weijun Chen ,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: lijunhua@genomics.cn (JL); chenwj@bgi.com (WC); yangdong1975@sina.com (DY)

Affiliations BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China, BGI-Shenzhen, Shenzhen, China
⨯
[ ... ],
Dong Yang

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: lijunhua@genomics.cn (JL); chenwj@bgi.com (WC); yangdong1975@sina.com (DY)

Affiliations Second People's Hospital of Tibet Autonomous Region, Lhasa, China, China-Japan Friendship Hospital, Beijing, China
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Comprehensive characterization of plasma cell-free Echinococcus spp. DNA in echinococcosis patients using ultra-high-throughput sequencing

Jingkai Ji,
Bin Li,
Jingzhong Li,
Wangmu Danzeng,
Jiandong Li,
Yanping Zhao,
Gezhen Qiangba,
Qingda Zhang,
Nibu Renzhen,
Zhuoga Basang

Published: April 13, 2020
https://doi.org/10.1371/journal.pntd.0008148

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