Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis

Carolina Ferreira; Inês Mesquita; Ana Margarida Barbosa; Nuno Sampaio Osório; Egídio Torrado; Charles-Joly Beauparlant; Arnaud Droit; Cristina Cunha; Agostinho Carvalho; Bhaskar Saha; Jerôme Estaquier; Ricardo Silvestre

doi:10.1371/journal.pntd.0008125

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Open Access

Peer-reviewed

Research Article

Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis

Carolina Ferreira,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliations Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal, ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Inês Mesquita,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal, ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Ana Margarida Barbosa,

Roles Investigation, Methodology

Affiliations Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal, ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Nuno Sampaio Osório,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliations Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal, ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Egídio Torrado,

Roles Resources, Writing – review & editing

Affiliations Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal, ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Charles-Joly Beauparlant,

Roles Data curation, Formal analysis

Affiliations Département de Médecine Moléculaire—Université Laval, Faculté de médecine, Québec, Canada, Centre de Recherche du CHU de Québec—Université Laval, Québec, Canada
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Arnaud Droit,

Roles Data curation, Formal analysis

Affiliations Département de Médecine Moléculaire—Université Laval, Faculté de médecine, Québec, Canada, Centre de Recherche du CHU de Québec—Université Laval, Québec, Canada
⨯
Cristina Cunha,

Roles Resources, Writing – review & editing

Affiliations Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal, ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Agostinho Carvalho,

Roles Resources, Writing – review & editing

Affiliations Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal, ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Bhaskar Saha,

Roles Conceptualization, Writing – review & editing

Affiliations National Centre for Cell Science, Pune, India, Trident Academy of Creative Technology, Bhubaneswar, Odisha, India
⨯
Jerôme Estaquier,

Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing

Affiliations Centre de Recherche du CHU de Québec—Université Laval, Québec, Canada, INSERM U1124, Université de Paris, Paris, France
⨯
Ricardo Silvestre

Roles Conceptualization, Data curation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

* E-mail: ricardosilvestre@med.uminho.pt

Affiliations Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal, ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal

http://orcid.org/0000-0002-9270-2717

⨯

Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis

Carolina Ferreira,
Inês Mesquita,
Ana Margarida Barbosa,
Nuno Sampaio Osório,
Egídio Torrado,
Charles-Joly Beauparlant,
Arnaud Droit,
Cristina Cunha,
Agostinho Carvalho,
Bhaskar Saha

Published: March 26, 2020
https://doi.org/10.1371/journal.pntd.0008125

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