A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell’s viper antivenom in Myanmar

• James A. Watson ,

  Contributed equally to this work with: James A. Watson, Thomas Lamb

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft, Writing – review & editing

  * E-mail: jwatowatson@gmail.com

  Affiliations Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0001-5524-0325

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• Thomas Lamb ,

  Contributed equally to this work with: James A. Watson, Thomas Lamb

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliations Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Myanmar-Oxford Clinical Research Unit, Yangon, Myanmar

  https://orcid.org/0000-0001-6102-2981

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• Jane Holmes,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Centre for Statistics in Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0001-7123-0004

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• David A. Warrell,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0001-7792-1615

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• Khin Thida Thwin,

  Roles Validation, Writing – review & editing

  Affiliation University of Medicine 1, Yangon, Myanmar

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• Zaw Lynn Aung,

  Roles Validation, Writing – review & editing

  Affiliation University of Medicine 1, Yangon, Myanmar

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• Min Zaw Oo,

  Roles Writing – review & editing

  Affiliation University of Medicine 2, Yangon, Myanmar

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• Myat Thet Nwe,

  Roles Validation, Writing – review & editing

  Affiliation Myanmar-Oxford Clinical Research Unit, Yangon, Myanmar

  https://orcid.org/0000-0001-7136-8636

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• Frank Smithuis,

  Roles Conceptualization, Funding acquisition, Methodology, Validation, Writing – review & editing

  Affiliations Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Myanmar-Oxford Clinical Research Unit, Yangon, Myanmar

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• Elizabeth A. Ashley

  Roles Conceptualization, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  Affiliations Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Myanmar-Oxford Clinical Research Unit, Yangon, Myanmar, Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Vientiane, Laos

  https://orcid.org/0000-0002-7620-4822

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