C19orf66 interrupts Zika virus replication by inducing lysosomal degradation of viral NS3

Yun Wu; Xinyu Yang; Zhicheng Yao; Xinhuai Dong; Danrui Zhang; Yiwen Hu; Shihao Zhang; Jiajie Lin; Jiahui Chen; Shu An; Hengming Ye; Shuqing Zhang; Ziying Qiu; Zhenjian He; Mingxing Huang; Guohong Wei; Xun Zhu

doi:10.1371/journal.pntd.0008083

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Open Access

Peer-reviewed

Research Article

C19orf66 interrupts Zika virus replication by inducing lysosomal degradation of viral NS3

Yun Wu ,

Contributed equally to this work with: Yun Wu, Xinyu Yang, Zhicheng Yao, Xinhuai Dong

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
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Xinyu Yang ,

Contributed equally to this work with: Yun Wu, Xinyu Yang, Zhicheng Yao, Xinhuai Dong

Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

Affiliation Depatment of Haematology, The Third Xiangya Hospital, Central South University, Changsha, China
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Zhicheng Yao ,

Contributed equally to this work with: Yun Wu, Xinyu Yang, Zhicheng Yao, Xinhuai Dong

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of General Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Xinhuai Dong ,

Contributed equally to this work with: Yun Wu, Xinyu Yang, Zhicheng Yao, Xinhuai Dong

Roles Conceptualization, Data curation, Formal analysis, Methodology

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Center for Translational Medicine, Shunde Hospital, Southern Medical University, Foshan, China
⨯
Danrui Zhang,

Roles Data curation, Methodology

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Basic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Yiwen Hu,

Roles Conceptualization, Data curation, Methodology

Affiliation Changsha Customs District P.R. China, Changsha, China
⨯
Shihao Zhang,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Basic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Jiajie Lin,

Roles Conceptualization, Methodology

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Clinical Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Jiahui Chen,

Roles Conceptualization, Methodology

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Shu An,

Roles Conceptualization, Data curation, Methodology

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Hengming Ye,

Roles Data curation, Formal analysis, Methodology

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯
Shuqing Zhang,

Roles Data curation, Formal analysis, Methodology

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Ziying Qiu,

Roles Data curation, Methodology

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯
Zhenjian He,

Roles Formal analysis, Methodology

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯
Mingxing Huang ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

* E-mail: kindentstar@126.com (MH); sanwgh@163.com (GW); zhuxun8@mail.sysu.edu.cn (XZ)

Affiliation Department of Infectious Diseases, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China
⨯
Guohong Wei ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

* E-mail: kindentstar@126.com (MH); sanwgh@163.com (GW); zhuxun8@mail.sysu.edu.cn (XZ)

Affiliation Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
⨯
[ ... ],
Xun Zhu

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: kindentstar@126.com (MH); sanwgh@163.com (GW); zhuxun8@mail.sysu.edu.cn (XZ)

Affiliations Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

http://orcid.org/0000-0001-5376-490X

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C19orf66 interrupts Zika virus replication by inducing lysosomal degradation of viral NS3

Yun Wu,
Xinyu Yang,
Zhicheng Yao,
Xinhuai Dong,
Danrui Zhang,
Yiwen Hu,
Shihao Zhang,
Jiajie Lin,
Jiahui Chen,
Shu An

Published: March 9, 2020
https://doi.org/10.1371/journal.pntd.0008083

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